% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Klyscz:257690,
      author       = {Klyscz, Philipp and Ihl, Thomas and Laumeier, Inga and
                      Steinicke, Maureen and Endres, Matthias and Michelson, Georg
                      and Audebert, Heinrich J},
      title        = {{R}etinal microvascular signs and recurrent vascular events
                      in patients with {TIA} or minor stroke.},
      journal      = {Stroke and vascular neurology},
      volume       = {8},
      number       = {5},
      issn         = {2059-8688},
      address      = {London},
      publisher    = {BMJ},
      reportid     = {DZNE-2023-00487},
      pages        = {379-386},
      year         = {2023},
      abstract     = {Retinal pathologies are an independent risk factor for
                      ischaemic stroke, but research on the predictive value of
                      retinal abnormalities for recurrent vascular events in
                      patients with prior stroke is inconclusive. We investigated
                      the association of retinal pathologies with subsequent
                      vascular events.In a substudy of the Intensified secondary
                      prevention intending a reduction of recurrent events in TIA
                      and minor stroke patients (INSPiRE-TMS) trial, we enrolled
                      patients with recent transient ischaemic attack (TIA) or
                      minor stroke with at least one modifiable risk factor.
                      Primary outcome was the composite of subsequent vascular
                      events. Retinal photographs were taken at baseline and
                      categorised into three different fundus groups by a
                      telemedically linked ophthalmologist.722 patients
                      participated in the current study and 109 major vascular
                      events occurred. After multivariable adjustments, we did not
                      find a significant association between fundus categories and
                      risk for subsequent vascular events (HRs for moderate
                      vascular retinopathy and vascular retinopathy with vessel
                      rarefaction in comparison to no vascular retinopathy 1.03
                      $(95\%$ CI 0.64 to 1.67), p=0.905 and 1.17 $(95\%$ CI 0.62
                      to 2.20), p=0.626). In a selective post hoc analysis in
                      patients with diabetes mellitus and hypertension, patients
                      with vascular retinopathy with vessel rarefaction had a
                      higher risk for recurrent stroke (HR 24.14 $(95\%$ CI 2.74
                      to 212.50), p=0.004).Retinal changes did not predict major
                      subsequent vascular events in patients with recent TIA or
                      minor stroke. Further studies are needed to examine the
                      utility of fundus photography in assessing the risk of
                      stroke recurrence in patients with diabetes mellitus and
                      hypertension.},
      keywords     = {Humans / Stroke: diagnosis / Stroke: epidemiology / Stroke:
                      complications / Ischemic Attack, Transient: diagnosis /
                      Brain Ischemia / Hypertension: complications / Retinal
                      Diseases: diagnosis / Retinal Diseases: epidemiology /
                      Retinal Diseases: complications / Diabetes Mellitus /
                      cerebral infarction (Other) / ischemic attack, transient
                      (Other) / stroke (Other)},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10647888},
      pubmed       = {pmid:36858463},
      doi          = {10.1136/svn-2022-001784},
      url          = {https://pub.dzne.de/record/257690},
}