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000257693 0247_ $$2ISSN$$a1476-5578
000257693 037__ $$aDZNE-2023-00490
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000257693 1001_ $$0P:(DE-2719)2814117$$aToda, Tomohisa$$b0$$udzne
000257693 245__ $$aThe role of adult hippocampal neurogenesis in brain health and disease.
000257693 260__ $$aLondon$$bMacmillan$$c2019
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000257693 520__ $$aAdult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.
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000257693 650_2 $$2MeSH$$aAdult
000257693 650_2 $$2MeSH$$aAffect: physiology
000257693 650_2 $$2MeSH$$aBrain: pathology
000257693 650_2 $$2MeSH$$aBrain: physiology
000257693 650_2 $$2MeSH$$aBrain Diseases: pathology
000257693 650_2 $$2MeSH$$aDentate Gyrus: pathology
000257693 650_2 $$2MeSH$$aDentate Gyrus: physiology
000257693 650_2 $$2MeSH$$aHippocampus: metabolism
000257693 650_2 $$2MeSH$$aHippocampus: pathology
000257693 650_2 $$2MeSH$$aHippocampus: physiology
000257693 650_2 $$2MeSH$$aHumans
000257693 650_2 $$2MeSH$$aMemory: physiology
000257693 650_2 $$2MeSH$$aNeurogenesis: physiology
000257693 650_2 $$2MeSH$$aNeuronal Plasticity: physiology
000257693 650_2 $$2MeSH$$aNeurons: physiology
000257693 650_2 $$2MeSH$$aTemporal Lobe: pathology
000257693 7001_ $$aParylak, Sarah L$$b1
000257693 7001_ $$aLinker, Sara B$$b2
000257693 7001_ $$aGage, Fred H$$b3
000257693 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-018-0036-2$$gVol. 24, no. 1, p. 67 - 87$$n1$$p67 - 87$$tMolecular psychiatry$$v24$$x1359-4184$$y2019
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