Journal Article (Review Article)

DZNE-2023-00490

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The role of adult hippocampal neurogenesis in brain health and disease.

Toda, T.Extern* ; Parylak, S. L. ; Linker, S. B. ; Gage, F. H.

2019
Macmillan London

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Please use a persistent id in citations: doi:10.1038/s41380-018-0036-2

Abstract: Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.

Keyword(s): Adult (MeSH) ; Affect: physiology (MeSH) ; Brain: pathology (MeSH) ; Brain: physiology (MeSH) ; Brain Diseases: pathology (MeSH) ; Dentate Gyrus: pathology (MeSH) ; Dentate Gyrus: physiology (MeSH) ; Hippocampus: metabolism (MeSH) ; Hippocampus: pathology (MeSH) ; Hippocampus: physiology (MeSH) ; Humans (MeSH) ; Memory: physiology (MeSH) ; Neurogenesis: physiology (MeSH) ; Neuronal Plasticity: physiology (MeSH) ; Neurons: physiology (MeSH) ; Temporal Lobe: pathology (MeSH)

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Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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