TY  - JOUR
AU  - Toda, Tomohisa
AU  - Parylak, Sarah L
AU  - Linker, Sara B
AU  - Gage, Fred H
TI  - The role of adult hippocampal neurogenesis in brain health and disease.
JO  - Molecular psychiatry
VL  - 24
IS  - 1
SN  - 1359-4184
CY  - London
PB  - Macmillan
M1  - DZNE-2023-00490
SP  - 67 - 87
PY  - 2019
AB  - Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.
KW  - Adult
KW  - Affect: physiology
KW  - Brain: pathology
KW  - Brain: physiology
KW  - Brain Diseases: pathology
KW  - Dentate Gyrus: pathology
KW  - Dentate Gyrus: physiology
KW  - Hippocampus: metabolism
KW  - Hippocampus: pathology
KW  - Hippocampus: physiology
KW  - Humans
KW  - Memory: physiology
KW  - Neurogenesis: physiology
KW  - Neuronal Plasticity: physiology
KW  - Neurons: physiology
KW  - Temporal Lobe: pathology
LB  - PUB:(DE-HGF)16
C6  - pmid:29679070
C2  - pmc:PMC6195869
DO  - DOI:10.1038/s41380-018-0036-2
UR  - https://pub.dzne.de/record/257693
ER  -