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024 7 _ |a 10.1038/s41380-018-0036-2
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024 7 _ |a 1359-4184
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024 7 _ |a 1476-5578
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037 _ _ |a DZNE-2023-00490
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Toda, Tomohisa
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245 _ _ |a The role of adult hippocampal neurogenesis in brain health and disease.
260 _ _ |a London
|c 2019
|b Macmillan
336 7 _ |a article
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520 _ _ |a Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis. Here we review a possible link between the physiological functions of adult-born neurons and their roles in pathological conditions.
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650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Affect: physiology
|2 MeSH
650 _ 2 |a Brain: pathology
|2 MeSH
650 _ 2 |a Brain: physiology
|2 MeSH
650 _ 2 |a Brain Diseases: pathology
|2 MeSH
650 _ 2 |a Dentate Gyrus: pathology
|2 MeSH
650 _ 2 |a Dentate Gyrus: physiology
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Hippocampus: pathology
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Memory: physiology
|2 MeSH
650 _ 2 |a Neurogenesis: physiology
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Temporal Lobe: pathology
|2 MeSH
700 1 _ |a Parylak, Sarah L
|b 1
700 1 _ |a Linker, Sara B
|b 2
700 1 _ |a Gage, Fred H
|b 3
773 _ _ |a 10.1038/s41380-018-0036-2
|g Vol. 24, no. 1, p. 67 - 87
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