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000257694 0247_ $$2doi$$a10.1016/j.stem.2017.08.012
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000257694 0247_ $$2ISSN$$a1875-9777
000257694 037__ $$aDZNE-2023-00491
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000257694 1001_ $$0P:(DE-2719)2814117$$aToda, Tomohisa$$b0$$udzne
000257694 245__ $$aNup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.
000257694 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2017
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000257694 520__ $$aNeural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differentiation. Genome-wide analyses show that Nup153 and Sox2 bind and co-regulate hundreds of genes. Binding of Nup153 to gene promoters or transcriptional end sites correlates with increased or decreased gene expression, respectively, and inhibiting Nup153 expression alters open chromatin configurations at its target genes, disrupts genomic localization of Sox2, and promotes differentiation in vitro and a gliogenic fate switch in vivo. Together, these findings reveal that nuclear structural proteins may exert bimodal transcriptional effects to control cell fate.
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000257694 650_7 $$2Other$$aNup153
000257694 650_7 $$2Other$$aSox2
000257694 650_7 $$2Other$$aadult neurogenesis
000257694 650_7 $$2Other$$abimodal gene regulation
000257694 650_7 $$2Other$$acell fate
000257694 650_7 $$2Other$$akey transcription factors
000257694 650_7 $$2Other$$aneural differentiation
000257694 650_7 $$2Other$$aneural progenitor cells
000257694 650_7 $$2Other$$anucleoporins
000257694 650_7 $$2Other$$aspatial transcriptional regulation
000257694 650_7 $$2NLM Chemicals$$aChromatin
000257694 650_7 $$2NLM Chemicals$$aNuclear Pore Complex Proteins
000257694 650_7 $$2NLM Chemicals$$aNup153 protein, mouse
000257694 650_7 $$2NLM Chemicals$$aSOXB1 Transcription Factors
000257694 650_2 $$2MeSH$$aAnimals
000257694 650_2 $$2MeSH$$aChromatin: metabolism
000257694 650_2 $$2MeSH$$aGene Expression Regulation
000257694 650_2 $$2MeSH$$aGenome
000257694 650_2 $$2MeSH$$aMice
000257694 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000257694 650_2 $$2MeSH$$aNeurogenesis: genetics
000257694 650_2 $$2MeSH$$aNuclear Pore Complex Proteins: metabolism
000257694 650_2 $$2MeSH$$aProtein Binding
000257694 650_2 $$2MeSH$$aSOXB1 Transcription Factors: metabolism
000257694 650_2 $$2MeSH$$aTranscription, Genetic
000257694 7001_ $$aHsu, Jonathan Y$$b1
000257694 7001_ $$aLinker, Sara B$$b2
000257694 7001_ $$aHu, Lauren$$b3
000257694 7001_ $$aSchafer, Simon T$$b4
000257694 7001_ $$aMertens, Jerome$$b5
000257694 7001_ $$aJacinto, Filipe V$$b6
000257694 7001_ $$aHetzer, Martin W$$b7
000257694 7001_ $$aGage, Fred H$$b8
000257694 773__ $$0PERI:(DE-600)2375356-0$$a10.1016/j.stem.2017.08.012$$gVol. 21, no. 5, p. 618 - 634.e7$$n5$$p618 - 634.e7$$tCell stem cell$$v21$$x1934-5909$$y2017
000257694 8564_ $$uhttps://pub.dzne.de/record/257694/files/DZNE-2023-00491.pdf
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