In process

There is a wide treatment heterogeneity for asphyxiated newborn infants between hospitals in Germany. This study aimed to identify the leading entry criteria initiating therapeutic hypothermia (TH) using data from the German Hypothermia Registry.We retrospectively analyzed 262 asphyxiated newborn infants treated with TH across 74 neonatal units in Germany. [...]

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, with both genetic and environmental risk factors. While traditionally, a relapsing and progressive disease course has been distinguished, it has increasingly become evident that elements of progression are the dominant factor for accumulating MS-related neurologic disability across all clinical courses and can be detected throughout the full disease trajectory in patients with MS. [...]

Motor performance (MP) is essential for maintaining functional independence, particularly in later life. However, the relationship between MP and sleep quality, depressive symptoms, and their underlying brain substrates remains obscure. [...]

The brain's perineuronal extracellular matrix (ECM) is a crucial factor in maintaining the stability of mature brain circuitry. However, how activity-induced synaptic plasticity is achieved in the adult brain with a dense ECM is unclear. [...]

The cortical asymmetry index evaluates the cortical thickness asymmetry between hemispheres. We investigated cortical asymmetry index in asymptomatic and symptomatic mutation carriers of autosomal dominant Alzheimer's disease to explore the brain asymmetry within the Alzheimer's disease continuum. [...]

Background: Conventional blood sampling for the testing of Alzheimer's disease (AD) biomarkers depends on stringent, time-sensitive, and temperature-dependent protocols for processing, shipping, and storage. Dry plasma spots (DPS) present a simpler, more scalable alternative for the collection, storage, and transport of blood samples and may offer an alternative sampling when access to blood volume is limited. [...]

Noninvasive measurement of the human brain's angioarchitecture is essential for understanding functional neuroimaging signals, diagnosing cerebrovascular diseases, and tracking neurodegeneration. Ultrahigh-field MRI now enables mesoscopic (<0.5 millimeters) imaging, revealing vascular details previously inaccessible in vivo. [...]

Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for NCDs in memory clinics. The SIGNATURE initiative aims to optimize the use of socio-cognitive measures in memory clinics, defining expert recommendations. [...]

Hunger and satiety are influenced by both the amount and composition of dietary fat.This exploratory analysis examined the effects of meals enriched with different amounts of either canola oil (rich in unsaturated fatty acids) or coconut oil (rich in saturated fatty acids) on postprandial changes in subjective hunger and satiety ratings, related hormones, attention, and memory.Twenty-nine participants with an increased cardiometabolic disease risk (e.g., body mass index, 30.2 ± 2.6 kg/m2) received 4 isoenergetic (∼4200 kJ) test meals in a randomized order: high-fat meals (HFMs) (50 g) or low-fat meals (LFMs) (25 g) containing either canola or coconut oil. Hunger and satiety ratings, blood samples for ghrelin and peptide YY (PYY), and cognitive tests were conducted at fasting and over a 6-h postprandial period. [...]

VPS13A disease (chorea-acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease.We systematically assessed the neuromuscular involvement in six patients with VPS13A disease. [...]