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000257786 037__ $$aDZNE-2023-00501
000257786 041__ $$aEnglish
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000257786 1001_ $$00000-0003-0078-0089$$aSaber Marouf, Babak$$b0$$eFirst author
000257786 245__ $$aTRPC4 Channel Knockdown in the Hippocampal CA1 Region Impairs Modulation of Beta Oscillations in Novel Context.
000257786 260__ $$aBasel$$bMDPI$$c2023
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000257786 520__ $$aHippocampal local field potentials (LFP) are highly related to behavior and memory functions. It has been shown that beta band LFP oscillations are correlated with contextual novelty and mnemonic performance. Evidence suggests that changes in neuromodulators, such as acetylcholine and dopamine, during exploration in a novel environment underlie changes in LFP. However, potential downstream mechanisms through which neuromodulators may alter the beta band oscillation in vivo remain to be fully understood. In this paper, we study the role of the membrane cationic channel TRPC4, which is modulated by various neuromodulators through G-protein-coupled receptors, by combining shRNA-mediated TRPC4 knockdown (KD) with LFP measurements in the CA1 region of the hippocampus in behaving mice. We demonstrate that the increased beta oscillation power seen in the control group mice in a novel environment is absent in the TRPC4 KD group. A similar loss of modulation was also seen in the low-gamma band oscillations in the TRPC4 KD group. These results demonstrate that TRPC4 channels are involved in the novelty-induced modulation of beta and low-gamma oscillations in the CA1 region.
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000257786 650_7 $$2Other$$aCA1
000257786 650_7 $$2Other$$aTRPC4
000257786 650_7 $$2Other$$abeta oscillations
000257786 650_7 $$2Other$$aencoding
000257786 650_7 $$2Other$$ahippocampus
000257786 650_7 $$2Other$$amemory
000257786 650_7 $$2Other$$anovel environment task
000257786 7001_ $$0P:(DE-2719)2813728$$aReboreda, Antonio$$b1$$udzne
000257786 7001_ $$0P:(DE-2719)2811872$$aTheissen, Frederik$$b2$$udzne
000257786 7001_ $$0P:(DE-2719)2811394$$aKaushik, Rahul$$b3$$udzne
000257786 7001_ $$00000-0002-7586-6410$$aSauvage, Magdalena$$b4
000257786 7001_ $$0P:(DE-2719)2810577$$aDityatev, Alexander$$b5
000257786 7001_ $$0P:(DE-2719)2811873$$aYoshida, Motoharu$$b6$$eLast author$$udzne
000257786 773__ $$0PERI:(DE-600)2661517-4$$a10.3390/biology12040629$$gVol. 12, no. 4, p. 629 -$$n4$$p629$$tBiology$$v12$$x2079-7737$$y2023
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