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@ARTICLE{SaberMarouf:257786,
      author       = {Saber Marouf, Babak and Reboreda, Antonio and Theissen,
                      Frederik and Kaushik, Rahul and Sauvage, Magdalena and
                      Dityatev, Alexander and Yoshida, Motoharu},
      title        = {{TRPC}4 {C}hannel {K}nockdown in the {H}ippocampal {CA}1
                      {R}egion {I}mpairs {M}odulation of {B}eta {O}scillations in
                      {N}ovel {C}ontext.},
      journal      = {Biology},
      volume       = {12},
      number       = {4},
      issn         = {2079-7737},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2023-00501},
      pages        = {629},
      year         = {2023},
      abstract     = {Hippocampal local field potentials (LFP) are highly related
                      to behavior and memory functions. It has been shown that
                      beta band LFP oscillations are correlated with contextual
                      novelty and mnemonic performance. Evidence suggests that
                      changes in neuromodulators, such as acetylcholine and
                      dopamine, during exploration in a novel environment underlie
                      changes in LFP. However, potential downstream mechanisms
                      through which neuromodulators may alter the beta band
                      oscillation in vivo remain to be fully understood. In this
                      paper, we study the role of the membrane cationic channel
                      TRPC4, which is modulated by various neuromodulators through
                      G-protein-coupled receptors, by combining shRNA-mediated
                      TRPC4 knockdown (KD) with LFP measurements in the CA1 region
                      of the hippocampus in behaving mice. We demonstrate that the
                      increased beta oscillation power seen in the control group
                      mice in a novel environment is absent in the TRPC4 KD group.
                      A similar loss of modulation was also seen in the low-gamma
                      band oscillations in the TRPC4 KD group. These results
                      demonstrate that TRPC4 channels are involved in the
                      novelty-induced modulation of beta and low-gamma
                      oscillations in the CA1 region.},
      keywords     = {CA1 (Other) / TRPC4 (Other) / beta oscillations (Other) /
                      encoding (Other) / hippocampus (Other) / memory (Other) /
                      novel environment task (Other)},
      cin          = {AG Yoshida / AG Dityatev},
      ddc          = {570},
      cid          = {I:(DE-2719)1310011 / I:(DE-2719)1310007},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37106829},
      pmc          = {pmc:PMC10135742},
      doi          = {10.3390/biology12040629},
      url          = {https://pub.dzne.de/record/257786},
}