Home > Publications Database > Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. > print

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024 7 _ |a 10.26508/lsa.202201730
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037 _ _ |a DZNE-2023-00511
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Stroo, Esther
|b 0
245 _ _ |a Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain.
260 _ _ |a Heidelberg
|c 2023
|b EMBO Press
336 7 _ |a article
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520 _ _ |a In age-related neurodegenerative diseases, like Alzheimer's and Parkinson's, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm and human cell models for diseases. Whether SERF modifies amyloid pathology in mammalian brain, however, has remained unknown. Here, we generated conditional Serf2 knockout mice and found that full-body deletion of Serf2 delayed embryonic development, causing premature birth and perinatal lethality. Brain-specific Serf2 knockout mice, on the other hand, were viable, and showed no major behavioral or cognitive abnormalities. In a mouse model for amyloid-β aggregation, brain depletion of Serf2 altered the binding of structure-specific amyloid dyes, previously used to distinguish amyloid polymorphisms in the human brain. These results suggest that Serf2 depletion changed the structure of amyloid deposits, which was further supported by scanning transmission electron microscopy, but further study will be required to confirm this observation. Altogether, our data reveal the pleiotropic functions of SERF2 in embryonic development and in the brain and support the existence of modifying factors of amyloid deposition in mammalian brain, which offer possibilities for polymorphism-based interventions.
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650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 7 |a SERF2 protein, human
|2 NLM Chemicals
650 _ 7 |a Intracellular Signaling Peptides and Proteins
|2 NLM Chemicals
650 _ 7 |a Serf2 protein, mouse
|2 NLM Chemicals
650 _ 2 |a Brain: embryology
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Plaque, Amyloid: metabolism
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides: metabolism
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Embryonic Development: genetics
|2 MeSH
650 _ 2 |a Mammals: metabolism
|2 MeSH
650 _ 2 |a Intracellular Signaling Peptides and Proteins: metabolism
|2 MeSH
700 1 _ |a Janssen, Leen
|0 0000-0002-1973-304X
|b 1
700 1 _ |a Sin, Olga
|b 2
700 1 _ |a Hogewerf, Wytse
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700 1 _ |a Koster, Mirjam
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700 1 _ |a Harkema, Liesbeth
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700 1 _ |a Youssef, Sameh A
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700 1 _ |a Beschorner, Natalie
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700 1 _ |a Wolters, Anouk Hg
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700 1 _ |a Bakker, Bjorn
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700 1 _ |a Becker, Lore
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700 1 _ |a Garrett, Lilian
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700 1 _ |a Marschall, Susan
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700 1 _ |a Hoelter, Sabine M
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700 1 _ |a Wurst, Wolfgang
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700 1 _ |a Fuchs, Helmut
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700 1 _ |a Gailus-Durner, Valerie
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700 1 _ |a Hrabe de Angelis, Martin
|0 0000-0002-7898-2353
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700 1 _ |a Thathiah, Amantha
|0 0000-0002-3132-4409
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700 1 _ |a Foijer, Floris
|0 0000-0003-0989-3127
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700 1 _ |a van de Sluis, Bart
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700 1 _ |a van Deursen, Jan
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700 1 _ |a Jucker, Matthias
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700 1 _ |a de Bruin, Alain
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700 1 _ |a Nollen, Ellen Aa
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773 _ _ |a 10.26508/lsa.202201730
|g Vol. 6, no. 7, p. e202201730 -
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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