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@ARTICLE{Dhler:257999,
      author       = {Döhler, Juliane and Northall, Alicia and Liu, Peng and
                      Fracasso, Alessio and Chrysidou, Anastasia and Speck, Oliver
                      and Lohmann, Gabriele and Wolbers, Thomas and Kuehn, Esther},
      title        = {{T}he 3{D} {S}tructural {A}rchitecture of the {H}uman
                      {H}and {A}rea {I}s {N}ontopographic.},
      journal      = {The journal of neuroscience},
      volume       = {43},
      number       = {19},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {DZNE-2023-00529},
      pages        = {3456 - 3476},
      year         = {2023},
      abstract     = {The functional topography of the human primary
                      somatosensory cortex hand area is a widely studied model
                      system to understand sensory organization and plasticity. It
                      is so far unclear whether the underlying 3D structural
                      architecture also shows a topographic organization. We used
                      7 Tesla (7T) magnetic resonance imaging (MRI) data to
                      quantify layer-specific myelin, iron, and mineralization in
                      relation to population receptive field maps of individual
                      finger representations in Brodman area 3b (BA 3b) of human
                      S1 in female and male younger adults. This 3D description
                      allowed us to identify a characteristic profile of
                      layer-specific myelin and iron deposition in the BA 3b hand
                      area, but revealed an absence of structural differences, an
                      absence of low-myelin borders, and high similarity of 3D
                      microstructure profiles between individual fingers. However,
                      structural differences and borders were detected between the
                      hand and face areas. We conclude that the 3D structural
                      architecture of the human hand area is nontopographic,
                      unlike in some monkey species, which suggests a high degree
                      of flexibility for functional finger organization and a new
                      perspective on human topographic plasticity.SIGNIFICANCE
                      STATEMENT Using ultra-high-field MRI, we provide the first
                      comprehensive in vivo description of the 3D structural
                      architecture of the human BA 3b hand area in relation to
                      functional population receptive field maps. High similarity
                      of precise finger-specific 3D profiles, together with an
                      absence of structural differences and an absence of
                      low-myelin borders between individual fingers, reveals the
                      3D structural architecture of the human hand area to be
                      nontopographic. This suggests reduced structural limitations
                      to cortical plasticity and reorganization and allows for
                      shared representational features across fingers.},
      keywords     = {Adult / Humans / Male / Female / Somatosensory Cortex /
                      Hand / Fingers / Cerebral Cortex / Magnetic Resonance
                      Imaging / Brain Mapping: methods / UHF MRI (Other) /
                      cortical field (Other) / in vivo myeloarchitecture (Other) /
                      parcellation (Other) / quantitative imaging (Other) / septa
                      (Other)},
      cin          = {AG Gasser / AG Düzel 3 / AG Schreiber / AG Wolbers / AG
                      Speck},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)5000006 /
                      I:(DE-2719)1310010 / I:(DE-2719)1310002 /
                      I:(DE-2719)1340009},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37001994},
      pmc          = {pmc:PMC10184749},
      doi          = {10.1523/JNEUROSCI.1692-22.2023},
      url          = {https://pub.dzne.de/record/257999},
}