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000258093 1001_ $$aNeumann, Wolf-Julian$$b0
000258093 245__ $$aInsights and opportunities for deep brain stimulation as a brain circuit intervention.
000258093 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
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000258093 520__ $$aDeep brain stimulation (DBS) is an effective treatment and has provided unique insights into the dynamic circuit architecture of brain disorders. This Review illustrates our current understanding of the pathophysiology of movement disorders and their underlying brain circuits that are modulated with DBS. It proposes principles of pathological network synchronization patterns like beta activity (13-35 Hz) in Parkinson's disease. We describe alterations from microscale including local synaptic activity via modulation of mesoscale hypersynchronization to changes in whole-brain macroscale connectivity. Finally, an outlook on advances for clinical innovations in next-generation neurotechnology is provided: from preoperative connectomic targeting to feedback controlled closed-loop adaptive DBS as individualized network-specific brain circuit interventions.
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000258093 650_2 $$2MeSH$$aHumans
000258093 650_2 $$2MeSH$$aDeep Brain Stimulation
000258093 650_2 $$2MeSH$$aParkinson Disease: therapy
000258093 650_2 $$2MeSH$$aBrain
000258093 650_2 $$2MeSH$$aConnectome
000258093 650_7 $$2Other$$abrain–computer interface
000258093 650_7 $$2Other$$abrain–computer interface
000258093 650_7 $$2Other$$abrain–computer interface
000258093 650_7 $$2Other$$abrain–computer interface
000258093 650_7 $$2Other$$aconnectomics
000258093 650_7 $$2Other$$aelectrocorticography
000258093 650_7 $$2Other$$alocal field potentials
000258093 650_7 $$2Other$$amovement disorders
000258093 650_7 $$2Other$$aneurophysiology
000258093 7001_ $$aHorn, Andreas$$b1
000258093 7001_ $$0P:(DE-2719)2811089$$aKühn, Andrea A$$b2$$eLast author$$udzne
000258093 773__ $$0PERI:(DE-600)2011000-5$$a10.1016/j.tins.2023.03.009$$gVol. 46, no. 6, p. 472 - 487$$n6$$p472 - 487$$tTrends in neurosciences$$v46$$x0378-5912$$y2023
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