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@ARTICLE{Neumann:258093,
      author       = {Neumann, Wolf-Julian and Horn, Andreas and Kühn, Andrea A},
      title        = {{I}nsights and opportunities for deep brain stimulation as
                      a brain circuit intervention.},
      journal      = {Trends in neurosciences},
      volume       = {46},
      number       = {6},
      issn         = {0378-5912},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2023-00555},
      pages        = {472 - 487},
      year         = {2023},
      abstract     = {Deep brain stimulation (DBS) is an effective treatment and
                      has provided unique insights into the dynamic circuit
                      architecture of brain disorders. This Review illustrates our
                      current understanding of the pathophysiology of movement
                      disorders and their underlying brain circuits that are
                      modulated with DBS. It proposes principles of pathological
                      network synchronization patterns like beta activity (13-35
                      Hz) in Parkinson's disease. We describe alterations from
                      microscale including local synaptic activity via modulation
                      of mesoscale hypersynchronization to changes in whole-brain
                      macroscale connectivity. Finally, an outlook on advances for
                      clinical innovations in next-generation neurotechnology is
                      provided: from preoperative connectomic targeting to
                      feedback controlled closed-loop adaptive DBS as
                      individualized network-specific brain circuit
                      interventions.},
      subtyp        = {Review Article},
      keywords     = {Humans / Deep Brain Stimulation / Parkinson Disease:
                      therapy / Brain / Connectome / brain–computer interface
                      (Other) / brain–computer interface (Other) /
                      brain–computer interface (Other) / brain–computer
                      interface (Other) / connectomics (Other) /
                      electrocorticography (Other) / local field potentials
                      (Other) / movement disorders (Other) / neurophysiology
                      (Other)},
      cin          = {Clinical Study Team Berlin 2 ; AG Kühn},
      ddc          = {610},
      cid          = {I:(DE-2719)5000008},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37105806},
      doi          = {10.1016/j.tins.2023.03.009},
      url          = {https://pub.dzne.de/record/258093},
}