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001     258093
005     20240403131202.0
024 7 _ |a 10.1016/j.tins.2023.03.009
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024 7 _ |a 0378-5912
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024 7 _ |a 0166-2236
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037 _ _ |a DZNE-2023-00555
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Neumann, Wolf-Julian
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245 _ _ |a Insights and opportunities for deep brain stimulation as a brain circuit intervention.
260 _ _ |a Amsterdam [u.a.]
|c 2023
|b Elsevier Science
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520 _ _ |a Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into the dynamic circuit architecture of brain disorders. This Review illustrates our current understanding of the pathophysiology of movement disorders and their underlying brain circuits that are modulated with DBS. It proposes principles of pathological network synchronization patterns like beta activity (13-35 Hz) in Parkinson's disease. We describe alterations from microscale including local synaptic activity via modulation of mesoscale hypersynchronization to changes in whole-brain macroscale connectivity. Finally, an outlook on advances for clinical innovations in next-generation neurotechnology is provided: from preoperative connectomic targeting to feedback controlled closed-loop adaptive DBS as individualized network-specific brain circuit interventions.
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588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Deep Brain Stimulation
|2 MeSH
650 _ 2 |a Parkinson Disease: therapy
|2 MeSH
650 _ 2 |a Brain
|2 MeSH
650 _ 2 |a Connectome
|2 MeSH
650 _ 7 |a brain–computer interface
|2 Other
650 _ 7 |a brain–computer interface
|2 Other
650 _ 7 |a brain–computer interface
|2 Other
650 _ 7 |a brain–computer interface
|2 Other
650 _ 7 |a connectomics
|2 Other
650 _ 7 |a electrocorticography
|2 Other
650 _ 7 |a local field potentials
|2 Other
650 _ 7 |a movement disorders
|2 Other
650 _ 7 |a neurophysiology
|2 Other
700 1 _ |a Horn, Andreas
|b 1
700 1 _ |a Kühn, Andrea A
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773 _ _ |a 10.1016/j.tins.2023.03.009
|g Vol. 46, no. 6, p. 472 - 487
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|p 472 - 487
|t Trends in neurosciences
|v 46
|y 2023
|x 0378-5912
856 4 _ |u https://pub.dzne.de/record/258093/files/DZNE-2023-00555.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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