TY  - JOUR
AU  - Klose, Veronika-Felicitas
AU  - Jesse, Sarah
AU  - Lewerenz, Jan
AU  - Kassubek, Jan
AU  - Dorst, Johannes
AU  - Tumani, Hayrettin
AU  - Ludolph, Albert C
AU  - Roselli, Francesco
TI  - CSF oligoclonal IgG bands are not associated with ALS progression and prognosis.
JO  - Frontiers in neurology
VL  - 14
SN  - 1664-2295
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2023-00560
SP  - 1170360
PY  - 2023
AB  - Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.IgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively collected in the Register Schabia.The prevalence of IgG OCB is comparable in ALS and the four neurological cohorts. When the OCB pattern was considered (highlighting either intrathecal or systemic B-cells activation), no effect of OCB pattern on clinic-demographic parameters and overall. ALS patients with intrathecal IgG synthesis (type 2 and 3) were more likely to display infectious, inflammatory or systemic autoimmune conditions.These data suggest that OCB are not related to ALS pathophysiology but rather are a finding possibly indicative a coincidental infectious or inflammatory comorbidity that merits further investigation.
KW  - age of onset (Other)
KW  - amyotrophic lateral sclerosis (Other)
KW  - cerebrospinal fluid (Other)
KW  - intrathecal synthesis (Other)
KW  - oligoclonal bands (Other)
KW  - survival (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37213901
C2  - pmc:PMC10196068
DO  - DOI:10.3389/fneur.2023.1170360
UR  - https://pub.dzne.de/record/258098
ER  -