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@ARTICLE{Klose:258098,
      author       = {Klose, Veronika-Felicitas and Jesse, Sarah and Lewerenz,
                      Jan and Kassubek, Jan and Dorst, Johannes and Tumani,
                      Hayrettin and Ludolph, Albert C and Roselli, Francesco},
      title        = {{CSF} oligoclonal {I}g{G} bands are not associated with
                      {ALS} progression and prognosis.},
      journal      = {Frontiers in neurology},
      volume       = {14},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2023-00560},
      pages        = {1170360},
      year         = {2023},
      abstract     = {Amyotrophic Lateral Sclerosis (ALS) is characterized by
                      progressive motoneuron degeneration through cell autonomous
                      and non-cell autonomous mechanisms; and the involvement of
                      the innate and adaptive immune system has been hypothesized
                      based on human and murine model data. We have explored if
                      B-cell activation and IgG responses, as detected by IgG
                      Oligoclonal bands (OCB) in serum and cerebrospinal fluid,
                      were associated with ALS or with a subgroup of patients with
                      distinct clinical features.IgG OCB were determined in
                      patients affected by ALS (n=457), Alzheimer Disease (n=516),
                      Mild Cognitive Impairment (n=91), Tension-type Headache
                      (n=152) and idiopathic Facial Palsy (n=94). For ALS
                      patients, clinico-demographic and survival data were
                      prospectively collected in the Register Schabia.The
                      prevalence of IgG OCB is comparable in ALS and the four
                      neurological cohorts. When the OCB pattern was considered
                      (highlighting either intrathecal or systemic B-cells
                      activation), no effect of OCB pattern on clinic-demographic
                      parameters and overall. ALS patients with intrathecal IgG
                      synthesis (type 2 and 3) were more likely to display
                      infectious, inflammatory or systemic autoimmune
                      conditions.These data suggest that OCB are not related to
                      ALS pathophysiology but rather are a finding possibly
                      indicative a coincidental infectious or inflammatory
                      comorbidity that merits further investigation.},
      keywords     = {age of onset (Other) / amyotrophic lateral sclerosis
                      (Other) / cerebrospinal fluid (Other) / intrathecal
                      synthesis (Other) / oligoclonal bands (Other) / survival
                      (Other)},
      cin          = {AG Roselli / AG Zhan ; AG Zhan / Clinical Study Center ;
                      Clinical Study Center Ulm},
      ddc          = {610},
      cid          = {I:(DE-2719)1910001 / I:(DE-2719)1910005 /
                      I:(DE-2719)5000077},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 354 - Disease
                      Prevention and Healthy Aging (POF4-354) / 353 - Clinical and
                      Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-354 /
                      G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37213901},
      pmc          = {pmc:PMC10196068},
      doi          = {10.3389/fneur.2023.1170360},
      url          = {https://pub.dzne.de/record/258098},
}