%0 Journal Article
%A Logroscino, Giancarlo
%A Piccininni, Marco
%A Graff, Caroline
%A Hardiman, Orla
%A Ludolph, Albert C
%A Moreno, Fermin
%A Otto, Markus
%A Remes, Anne M
%A Rowe, James B
%A Seelaar, Harro
%A Solje, Eino
%A Stefanova, Elka
%A Traykov, Latchezar
%A Jelic, Vesna
%A Rydell, Melissa Taheri
%A Pender, Niall
%A Anderl-Straub, Sarah
%A Barandiaran, Myriam
%A Gabilondo, Alazne
%A Krüger, Johanna
%A Murley, Alexander G
%A Rittman, Timothy
%A van der Ende, Emma L
%A van Swieten, John C
%A Hartikainen, Päivi
%A Stojmenovic, Gorana Mandic
%A Mehrabian, Shima
%A Benussi, Luisa
%A Alberici, Antonella
%A Dell'Abate, Maria Teresa
%A Zecca, Chiara
%A Borroni, Barbara
%T Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries.
%J JAMA neurology
%V 80
%N 3
%@ 2168-6149
%C Chicago, Ill.
%I American Medical Association
%M DZNE-2023-00566
%P 279 - 286
%D 2023
%X Diagnostic incidence data for syndromes associated with frontotemporal lobar degeneration (FTLD) in multinational studies are urgent in light of upcoming therapeutic approaches.To assess the incidence of FTLD across Europe.The Frontotemporal Dementia Incidence European Research Study (FRONTIERS) was a retrospective cohort study conducted from June 1, 2018, to May 31, 2019, using a population-based registry from 13 tertiary FTLD research clinics from the UK, the Netherlands, Finland, Sweden, Spain, Bulgaria, Serbia, Germany, and Italy and including all new FTLD-associated cases during the study period, with a combined catchment population of 11 023 643 person-years. Included patients fulfilled criteria for the behavioral variant of frontotemporal dementia (BVFTD), the nonfluent variant or semantic variant of primary progressive aphasia (PPA), unspecified PPA, progressive supranuclear palsy, corticobasal syndrome, or frontotemporal dementia with amyotrophic lateral sclerosis (FTD-ALS). Data were analyzed from July 19 to December 7, 2021.Random-intercept Poisson models were used to obtain estimates of the European FTLD incidence rate accounting for geographic heterogeneity.Based on 267 identified cases (mean [SD] patient age, 66.70 [9.02] years; 156 males [58.43
%K Male
%K Humans
%K Female
%K Aged
%K Frontotemporal Dementia: epidemiology
%K Incidence
%K Amyotrophic Lateral Sclerosis
%K Retrospective Studies
%K Frontotemporal Lobar Degeneration: epidemiology
%K Syndrome
%K Europe: epidemiology
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36716024
%2 pmc:PMC9887528
%R 10.1001/jamaneurol.2022.5128
%U https://pub.dzne.de/record/258104