TY  - JOUR
AU  - Logroscino, Giancarlo
AU  - Piccininni, Marco
AU  - Graff, Caroline
AU  - Hardiman, Orla
AU  - Ludolph, Albert C
AU  - Moreno, Fermin
AU  - Otto, Markus
AU  - Remes, Anne M
AU  - Rowe, James B
AU  - Seelaar, Harro
AU  - Solje, Eino
AU  - Stefanova, Elka
AU  - Traykov, Latchezar
AU  - Jelic, Vesna
AU  - Rydell, Melissa Taheri
AU  - Pender, Niall
AU  - Anderl-Straub, Sarah
AU  - Barandiaran, Myriam
AU  - Gabilondo, Alazne
AU  - Krüger, Johanna
AU  - Murley, Alexander G
AU  - Rittman, Timothy
AU  - van der Ende, Emma L
AU  - van Swieten, John C
AU  - Hartikainen, Päivi
AU  - Stojmenovic, Gorana Mandic
AU  - Mehrabian, Shima
AU  - Benussi, Luisa
AU  - Alberici, Antonella
AU  - Dell'Abate, Maria Teresa
AU  - Zecca, Chiara
AU  - Borroni, Barbara
TI  - Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries.
JO  - JAMA neurology
VL  - 80
IS  - 3
SN  - 2168-6149
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DZNE-2023-00566
SP  - 279 - 286
PY  - 2023
AB  - Diagnostic incidence data for syndromes associated with frontotemporal lobar degeneration (FTLD) in multinational studies are urgent in light of upcoming therapeutic approaches.To assess the incidence of FTLD across Europe.The Frontotemporal Dementia Incidence European Research Study (FRONTIERS) was a retrospective cohort study conducted from June 1, 2018, to May 31, 2019, using a population-based registry from 13 tertiary FTLD research clinics from the UK, the Netherlands, Finland, Sweden, Spain, Bulgaria, Serbia, Germany, and Italy and including all new FTLD-associated cases during the study period, with a combined catchment population of 11 023 643 person-years. Included patients fulfilled criteria for the behavioral variant of frontotemporal dementia (BVFTD), the nonfluent variant or semantic variant of primary progressive aphasia (PPA), unspecified PPA, progressive supranuclear palsy, corticobasal syndrome, or frontotemporal dementia with amyotrophic lateral sclerosis (FTD-ALS). Data were analyzed from July 19 to December 7, 2021.Random-intercept Poisson models were used to obtain estimates of the European FTLD incidence rate accounting for geographic heterogeneity.Based on 267 identified cases (mean [SD] patient age, 66.70 [9.02] years; 156 males [58.43
KW  - Male
KW  - Humans
KW  - Female
KW  - Aged
KW  - Frontotemporal Dementia: epidemiology
KW  - Incidence
KW  - Amyotrophic Lateral Sclerosis
KW  - Retrospective Studies
KW  - Frontotemporal Lobar Degeneration: epidemiology
KW  - Syndrome
KW  - Europe: epidemiology
LB  - PUB:(DE-HGF)16
C6  - pmid:36716024
C2  - pmc:PMC9887528
DO  - DOI:10.1001/jamaneurol.2022.5128
UR  - https://pub.dzne.de/record/258104
ER  -