%0 Journal Article
%A Göschel, Laura
%A Kurz, Lea
%A Dell Orco, Andrea
%A Köbe, Theresa
%A Körtvélyessy, Peter
%A Fillmer, Ariane
%A Aydin, Semiha
%A Riemann, Layla Tabea
%A Wang, Hui
%A Ittermann, Bernd
%A Grittner, Ulrike
%A Flöel, Agnes
%T 7T amygdala and hippocampus subfields in volumetry-based associations with memory: A 3-year follow-up study of early Alzheimer's disease.
%J NeuroImage: Clinical
%V 38
%@ 2213-1582
%C [Amsterdam u.a.]
%I Elsevier
%M DZNE-2023-00577
%P 103439
%D 2023
%X The hippocampus is the most prominent single region of interest (ROI) for the diagnosis and prediction of Alzheimer's disease (AD). However, its suitability in the earliest stages of cognitive decline, i.e., subjective cognitive decline (SCD), remains uncertain which warrants the pursuit of alternative or complementary regions. The amygdala might be a promising candidate, given its implication in memory as well as other psychiatric disorders, e.g. depression and anxiety, which are prevalent in SCD. In this 7 tesla (T) magnetic resonance imaging (MRI) study, we aimed to compare the contribution of volumetric measurements of the hippocampus, the amygdala, and their respective subfields, for early diagnosis and prediction in an AD-related study population.Participants from a longitudinal study were grouped into SCD (n = 29), mild cognitive impairment (MCI, n = 23), AD (n = 22) and healthy control (HC, n = 31). All participants underwent 7T MRI at baseline and extensive neuropsychological testing at up to three visits (baseline n = 105, 1-year n = 78, 3-year n = 39). Analysis of covariance (ANCOVA) was used to assess group differences of baseline volumes of the amygdala and the hippocampus and their subfields. Linear mixed models were used to estimate the effects of baseline volumes on yearly changes of a z-scaled memory score. All models were adjusted to age, sex and education.Compared to the HC group, individuals with SCD showed smaller amygdala ROI volumes (range across subfields -11
%K Humans
%K Follow-Up Studies
%K Alzheimer Disease: pathology
%K Longitudinal Studies
%K Cross-Sectional Studies
%K Cognitive Dysfunction: pathology
%K Magnetic Resonance Imaging
%K Amygdala: diagnostic imaging
%K Amygdala: pathology
%K Neuropsychological Tests
%K Memory Disorders: diagnostic imaging
%K Memory Disorders: etiology
%K Alzheimer’s disease (Other)
%K 7T MRI (Other)
%K Alzheimer’s disease (Other)
%K Amygdala (Other)
%K Hippocampus (Other)
%K Memory (Other)
%K SCD (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37253284
%2 pmc:PMC10236463
%R 10.1016/j.nicl.2023.103439
%U https://pub.dzne.de/record/258231