TY  - JOUR
AU  - Göschel, Laura
AU  - Kurz, Lea
AU  - Dell Orco, Andrea
AU  - Köbe, Theresa
AU  - Körtvélyessy, Peter
AU  - Fillmer, Ariane
AU  - Aydin, Semiha
AU  - Riemann, Layla Tabea
AU  - Wang, Hui
AU  - Ittermann, Bernd
AU  - Grittner, Ulrike
AU  - Flöel, Agnes
TI  - 7T amygdala and hippocampus subfields in volumetry-based associations with memory: A 3-year follow-up study of early Alzheimer's disease.
JO  - NeuroImage: Clinical
VL  - 38
SN  - 2213-1582
CY  - [Amsterdam u.a.]
PB  - Elsevier
M1  - DZNE-2023-00577
SP  - 103439
PY  - 2023
AB  - The hippocampus is the most prominent single region of interest (ROI) for the diagnosis and prediction of Alzheimer's disease (AD). However, its suitability in the earliest stages of cognitive decline, i.e., subjective cognitive decline (SCD), remains uncertain which warrants the pursuit of alternative or complementary regions. The amygdala might be a promising candidate, given its implication in memory as well as other psychiatric disorders, e.g. depression and anxiety, which are prevalent in SCD. In this 7 tesla (T) magnetic resonance imaging (MRI) study, we aimed to compare the contribution of volumetric measurements of the hippocampus, the amygdala, and their respective subfields, for early diagnosis and prediction in an AD-related study population.Participants from a longitudinal study were grouped into SCD (n = 29), mild cognitive impairment (MCI, n = 23), AD (n = 22) and healthy control (HC, n = 31). All participants underwent 7T MRI at baseline and extensive neuropsychological testing at up to three visits (baseline n = 105, 1-year n = 78, 3-year n = 39). Analysis of covariance (ANCOVA) was used to assess group differences of baseline volumes of the amygdala and the hippocampus and their subfields. Linear mixed models were used to estimate the effects of baseline volumes on yearly changes of a z-scaled memory score. All models were adjusted to age, sex and education.Compared to the HC group, individuals with SCD showed smaller amygdala ROI volumes (range across subfields -11
KW  - Humans
KW  - Follow-Up Studies
KW  - Alzheimer Disease: pathology
KW  - Longitudinal Studies
KW  - Cross-Sectional Studies
KW  - Cognitive Dysfunction: pathology
KW  - Magnetic Resonance Imaging
KW  - Amygdala: diagnostic imaging
KW  - Amygdala: pathology
KW  - Neuropsychological Tests
KW  - Memory Disorders: diagnostic imaging
KW  - Memory Disorders: etiology
KW  - Alzheimer’s disease (Other)
KW  - 7T MRI (Other)
KW  - Alzheimer’s disease (Other)
KW  - Amygdala (Other)
KW  - Hippocampus (Other)
KW  - Memory (Other)
KW  - SCD (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37253284
C2  - pmc:PMC10236463
DO  - DOI:10.1016/j.nicl.2023.103439
UR  - https://pub.dzne.de/record/258231
ER  -