TY  - JOUR
AU  - Helf, Charlotte
AU  - Kober, Maria
AU  - Markert, Franz
AU  - Lanto, Jennifer
AU  - Overhoff, Leonie
AU  - Badstübner-Meeske, Kathrin
AU  - Storch, Alexander
AU  - Fauser, Mareike
TI  - Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson's disease.
JO  - Neuroreport
VL  - 34
IS  - 10
SN  - 0959-4965
CY  - [Erscheinungsort nicht ermittelbar]
PB  - Ovid
M1  - DZNE-2023-00589
SP  - 506 - 511
PY  - 2023
AB  - Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been a highly effective treatment option for middle to late stage Parkinson's disease for decades. Though, the underlying mechanisms of action, particularly effects on the cellular level, remain in part unclear. In the context of identifying disease-modifying effects of STN-DBS by prompting cellular plasticity in midbrain dopaminergic systems, we analyzed neuronal tyrosine hydroxylase and c-Fos expression in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA).We applied 1 week of continuous unilateral STN-DBS in a group of stable 6-hydroxydopamine (6-OHDA) hemiparkinsonian rats (STNSTIM) in comparison to a 6-OHDA control group (STNSHAM). Immunohistochemistry identified NeuN+, tyrosine hydroxylase+ and c-Fos+ cells within the SNpc and VTA.After 1 week, rats in the STNSTIM group had 3.5-fold more tyrosine hydroxylase+ neurons within the SNpc (P = 0.010) but not in the VTA compared to sham controls. There was no difference in basal cell activity as indicated by c-Fos expression in both midbrain dopaminergic systems.Our data support a neurorestorative effect of STN-DBS in the nigrostriatal dopaminergic system already after 7 days of continuous STN-DBS in the stable Parkinson's disease rat model without affecting basal cell activity.
KW  - Rats
KW  - Animals
KW  - Parkinson Disease: therapy
KW  - Parkinson Disease: metabolism
KW  - Subthalamic Nucleus: metabolism
KW  - Oxidopamine: toxicity
KW  - Deep Brain Stimulation
KW  - Tyrosine 3-Monooxygenase: metabolism
KW  - Dopamine: metabolism
KW  - Substantia Nigra: metabolism
KW  - Oxidopamine (NLM Chemicals)
KW  - Tyrosine 3-Monooxygenase (NLM Chemicals)
KW  - Dopamine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37270842
C2  - pmc:PMC10234325
DO  - DOI:10.1097/WNR.0000000000001917
UR  - https://pub.dzne.de/record/258243
ER  -