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@ARTICLE{Helf:258243,
      author       = {Helf, Charlotte and Kober, Maria and Markert, Franz and
                      Lanto, Jennifer and Overhoff, Leonie and Badstübner-Meeske,
                      Kathrin and Storch, Alexander and Fauser, Mareike},
      title        = {{S}ubthalamic nucleus deep brain stimulation induces
                      nigrostriatal dopaminergic plasticity in a stable rat model
                      of {P}arkinson's disease.},
      journal      = {Neuroreport},
      volume       = {34},
      number       = {10},
      issn         = {0959-4965},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Ovid},
      reportid     = {DZNE-2023-00589},
      pages        = {506 - 511},
      year         = {2023},
      abstract     = {Deep brain stimulation (DBS) of the subthalamic nucleus
                      (STN) has been a highly effective treatment option for
                      middle to late stage Parkinson's disease for decades.
                      Though, the underlying mechanisms of action, particularly
                      effects on the cellular level, remain in part unclear. In
                      the context of identifying disease-modifying effects of
                      STN-DBS by prompting cellular plasticity in midbrain
                      dopaminergic systems, we analyzed neuronal tyrosine
                      hydroxylase and c-Fos expression in the substantia nigra
                      pars compacta (SNpc) and ventral tegmental area (VTA).We
                      applied 1 week of continuous unilateral STN-DBS in a group
                      of stable 6-hydroxydopamine (6-OHDA) hemiparkinsonian rats
                      (STNSTIM) in comparison to a 6-OHDA control group (STNSHAM).
                      Immunohistochemistry identified NeuN+, tyrosine hydroxylase+
                      and c-Fos+ cells within the SNpc and VTA.After 1 week, rats
                      in the STNSTIM group had 3.5-fold more tyrosine hydroxylase+
                      neurons within the SNpc (P = 0.010) but not in the VTA
                      compared to sham controls. There was no difference in basal
                      cell activity as indicated by c-Fos expression in both
                      midbrain dopaminergic systems.Our data support a
                      neurorestorative effect of STN-DBS in the nigrostriatal
                      dopaminergic system already after 7 days of continuous
                      STN-DBS in the stable Parkinson's disease rat model without
                      affecting basal cell activity.},
      keywords     = {Rats / Animals / Parkinson Disease: therapy / Parkinson
                      Disease: metabolism / Subthalamic Nucleus: metabolism /
                      Oxidopamine: toxicity / Deep Brain Stimulation / Tyrosine
                      3-Monooxygenase: metabolism / Dopamine: metabolism /
                      Substantia Nigra: metabolism / Oxidopamine (NLM Chemicals) /
                      Tyrosine 3-Monooxygenase (NLM Chemicals) / Dopamine (NLM
                      Chemicals)},
      cin          = {AG Storch 2 Rostock},
      ddc          = {610},
      cid          = {I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37270842},
      pmc          = {pmc:PMC10234325},
      doi          = {10.1097/WNR.0000000000001917},
      url          = {https://pub.dzne.de/record/258243},
}