%0 Journal Article
%A Xia, Kailin
%A Klose, Veronika
%A Högel, Josef
%A Huang, Tao
%A Zhang, Linjing
%A Dorst, Johannes
%A Fan, Dongsheng
%A Ludolph, Albert C
%T Lipids and amyotrophic lateral sclerosis: A two-sample Mendelian randomization study.
%J European journal of neurology
%V 30
%N 7
%@ 1351-5101
%C Oxford [u.a.]
%I Wiley-Blackwell
%M DZNE-2023-00592
%P 1899 - 1906
%D 2023
%X Previous observational studies revealed a potential but partially controversial relation between lipid metabolism and the risk of amyotrophic lateral sclerosis (ALS), potentially prone to bias. Therefore, we aimed to study whether lipid metabolism involves genetically determined risk factors for ALS through Mendelian randomization (MR) analysis.Using genome-wide association study summary-level data for total cholesterol (TC) (n = 188,578), high-density lipoprotein cholesterol (HDL-C) (n = 403,943), low-density lipoprotein cholesterol (LDL-C) (n = 440,546), apolipoprotein A1 (ApoA1) (n = 391,193), apolipoprotein B (ApoB) (n = 439,214), and ALS (12,577 cases and 23,475 controls), we implemented a bidirectional MR study to evaluate a genetic relation between lipids and ALS risk. We performed a mediation analysis to assess whether LDL-C is a potential mediator on the pathway from traits of LDL-C-related polyunsaturated fatty acids (PUFAs) to ALS risk.We identified genetically predicted increased lipid levels to be associated with the risk of ALS, whereby elevated LDL-C had the most potent effect (OR 1.028, 95
%K Humans
%K Amyotrophic Lateral Sclerosis: epidemiology
%K Amyotrophic Lateral Sclerosis: genetics
%K Cholesterol, LDL: genetics
%K Mendelian Randomization Analysis
%K Genome-Wide Association Study
%K Risk Factors
%K Polymorphism, Single Nucleotide
%K Triglycerides: genetics
%K Mendelian randomization (Other)
%K amyotrophic lateral sclerosis (Other)
%K genetics (Other)
%K instrumental variables (Other)
%K lipids (Other)
%K Cholesterol, LDL (NLM Chemicals)
%K Triglycerides (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36999624
%R 10.1111/ene.15810
%U https://pub.dzne.de/record/258246