TY  - JOUR
AU  - Xia, Kailin
AU  - Klose, Veronika
AU  - Högel, Josef
AU  - Huang, Tao
AU  - Zhang, Linjing
AU  - Dorst, Johannes
AU  - Fan, Dongsheng
AU  - Ludolph, Albert C
TI  - Lipids and amyotrophic lateral sclerosis: A two-sample Mendelian randomization study.
JO  - European journal of neurology
VL  - 30
IS  - 7
SN  - 1351-5101
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - DZNE-2023-00592
SP  - 1899 - 1906
PY  - 2023
AB  - Previous observational studies revealed a potential but partially controversial relation between lipid metabolism and the risk of amyotrophic lateral sclerosis (ALS), potentially prone to bias. Therefore, we aimed to study whether lipid metabolism involves genetically determined risk factors for ALS through Mendelian randomization (MR) analysis.Using genome-wide association study summary-level data for total cholesterol (TC) (n = 188,578), high-density lipoprotein cholesterol (HDL-C) (n = 403,943), low-density lipoprotein cholesterol (LDL-C) (n = 440,546), apolipoprotein A1 (ApoA1) (n = 391,193), apolipoprotein B (ApoB) (n = 439,214), and ALS (12,577 cases and 23,475 controls), we implemented a bidirectional MR study to evaluate a genetic relation between lipids and ALS risk. We performed a mediation analysis to assess whether LDL-C is a potential mediator on the pathway from traits of LDL-C-related polyunsaturated fatty acids (PUFAs) to ALS risk.We identified genetically predicted increased lipid levels to be associated with the risk of ALS, whereby elevated LDL-C had the most potent effect (OR 1.028, 95
KW  - Humans
KW  - Amyotrophic Lateral Sclerosis: epidemiology
KW  - Amyotrophic Lateral Sclerosis: genetics
KW  - Cholesterol, LDL: genetics
KW  - Mendelian Randomization Analysis
KW  - Genome-Wide Association Study
KW  - Risk Factors
KW  - Polymorphism, Single Nucleotide
KW  - Triglycerides: genetics
KW  - Mendelian randomization (Other)
KW  - amyotrophic lateral sclerosis (Other)
KW  - genetics (Other)
KW  - instrumental variables (Other)
KW  - lipids (Other)
KW  - Cholesterol, LDL (NLM Chemicals)
KW  - Triglycerides (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36999624
DO  - DOI:10.1111/ene.15810
UR  - https://pub.dzne.de/record/258246
ER  -