%0 Journal Article
%A Müller, Luisa
%A Power Guerra, Nicole
%A Schildt, Anna
%A Lindner, Tobias
%A Stenzel, Jan
%A Behrangi, Newshan
%A Bergner, Carina
%A Alberts, Teresa
%A Bühler, Daniel
%A Kurth, Jens
%A Krause, Bernd Joachim
%A Janowitz, Deborah
%A Teipel, Stefan
%A Vollmar, Brigitte
%A Kuhla, Angela
%T [18F]GE-180-PET and Post Mortem Marker Characteristics of Long-Term High-Fat-Diet-Induced Chronic Neuroinflammation in Mice.
%J Biomolecules
%V 13
%N 5
%@ 2218-273X
%C Basel
%I MDPI
%M DZNE-2023-00600
%P 769
%D 2023
%X Obesity is characterized by immoderate fat accumulation leading to an elevated risk of neurodegenerative disorders, along with a host of metabolic disturbances. Chronic neuroinflammation is a main factor linking obesity and the propensity for neurodegenerative disorders. To determine the cerebrometabolic effects of diet-induced obesity (DIO) in female mice fed a long-term (24 weeks) high-fat diet (HFD, 60
%K Mice
%K Female
%K Animals
%K Diet, High-Fat: adverse effects
%K Neuroinflammatory Diseases
%K Obesity: diagnostic imaging
%K Obesity: metabolism
%K Carrier Proteins
%K Neurodegenerative Diseases
%K Glucose
%K Positron-Emission Tomography: methods
%K Mice, Inbred C57BL
%K TSPO (Other)
%K [18F]FDG PET/CT (Other)
%K [18F]GE-180 PET/CT (Other)
%K diet-induced obesity (Other)
%K high-fat diet (Other)
%K neuroinflammation (Other)
%K GE-180 (NLM Chemicals)
%K Carrier Proteins (NLM Chemicals)
%K Glucose (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37238638
%2 pmc:PMC10216137
%R 10.3390/biom13050769
%U https://pub.dzne.de/record/258254