TY  - JOUR
AU  - Müller, Luisa
AU  - Power Guerra, Nicole
AU  - Schildt, Anna
AU  - Lindner, Tobias
AU  - Stenzel, Jan
AU  - Behrangi, Newshan
AU  - Bergner, Carina
AU  - Alberts, Teresa
AU  - Bühler, Daniel
AU  - Kurth, Jens
AU  - Krause, Bernd Joachim
AU  - Janowitz, Deborah
AU  - Teipel, Stefan
AU  - Vollmar, Brigitte
AU  - Kuhla, Angela
TI  - [18F]GE-180-PET and Post Mortem Marker Characteristics of Long-Term High-Fat-Diet-Induced Chronic Neuroinflammation in Mice.
JO  - Biomolecules
VL  - 13
IS  - 5
SN  - 2218-273X
CY  - Basel
PB  - MDPI
M1  - DZNE-2023-00600
SP  - 769
PY  - 2023
AB  - Obesity is characterized by immoderate fat accumulation leading to an elevated risk of neurodegenerative disorders, along with a host of metabolic disturbances. Chronic neuroinflammation is a main factor linking obesity and the propensity for neurodegenerative disorders. To determine the cerebrometabolic effects of diet-induced obesity (DIO) in female mice fed a long-term (24 weeks) high-fat diet (HFD, 60
KW  - Mice
KW  - Female
KW  - Animals
KW  - Diet, High-Fat: adverse effects
KW  - Neuroinflammatory Diseases
KW  - Obesity: diagnostic imaging
KW  - Obesity: metabolism
KW  - Carrier Proteins
KW  - Neurodegenerative Diseases
KW  - Glucose
KW  - Positron-Emission Tomography: methods
KW  - Mice, Inbred C57BL
KW  - TSPO (Other)
KW  - [18F]FDG PET/CT (Other)
KW  - [18F]GE-180 PET/CT (Other)
KW  - diet-induced obesity (Other)
KW  - high-fat diet (Other)
KW  - neuroinflammation (Other)
KW  - GE-180 (NLM Chemicals)
KW  - Carrier Proteins (NLM Chemicals)
KW  - Glucose (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37238638
C2  - pmc:PMC10216137
DO  - DOI:10.3390/biom13050769
UR  - https://pub.dzne.de/record/258254
ER  -