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000258661 1001_ $$aKapellos, Theodore S$$b0
000258661 245__ $$aSystemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.
000258661 260__ $$a[New York, NY]$$bElsevier$$c2023
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000258661 520__ $$aSystemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.
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000258661 650_7 $$2Other$$aCP: Immunology
000258661 650_7 $$2Other$$ablood
000258661 650_7 $$2Other$$abone marrow
000258661 650_7 $$2Other$$achronic obstructive pulmonary disease
000258661 650_7 $$2Other$$agranulopoiesis
000258661 650_7 $$2Other$$aneutrophil
000258661 650_7 $$2Other$$asingle-cell transcriptomics
000258661 650_2 $$2MeSH$$aHumans
000258661 650_2 $$2MeSH$$aAnimals
000258661 650_2 $$2MeSH$$aMice
000258661 650_2 $$2MeSH$$aNeutrophils
000258661 650_2 $$2MeSH$$aPulmonary Disease, Chronic Obstructive: drug therapy
000258661 650_2 $$2MeSH$$aLung
000258661 650_2 $$2MeSH$$aPulmonary Emphysema
000258661 650_2 $$2MeSH$$aInflammation
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000258661 7001_ $$0P:(DE-2719)9000836$$aBaßler, Kevin$$b1
000258661 7001_ $$aFujii, Wataru$$b2
000258661 7001_ $$aNalkurthi, Christina$$b3
000258661 7001_ $$aSchaar, Anna C$$b4
000258661 7001_ $$0P:(DE-2719)9001512$$aBonaguro, Lorenzo$$b5
000258661 7001_ $$0P:(DE-2719)9002574$$aPacht, Tal$$b6$$udzne
000258661 7001_ $$aGalvao, Izabela$$b7
000258661 7001_ $$0P:(DE-2719)9000463$$aAgrawal, Shobhit$$b8
000258661 7001_ $$0P:(DE-2719)2812564$$aSaglam, Adem$$b9
000258661 7001_ $$aDudkin, Erica$$b10
000258661 7001_ $$0P:(DE-2719)9001365$$aFrishberg, Amit$$b11
000258661 7001_ $$0P:(DE-2719)9000846$$ade Domenico, Elena$$b12
000258661 7001_ $$0P:(DE-2719)9002161$$aHorne, Arik$$b13
000258661 7001_ $$aDonovan, Chantal$$b14
000258661 7001_ $$aKim, Richard Y$$b15
000258661 7001_ $$aGallego-Ortega, David$$b16
000258661 7001_ $$aGillett, Tessa E$$b17
000258661 7001_ $$aAnsari, Meshal$$b18
000258661 7001_ $$0P:(DE-2719)9001500$$aSchulte-Schrepping, Jonas$$b19
000258661 7001_ $$0P:(DE-2719)2811777$$aOffermann, Nina$$b20
000258661 7001_ $$0P:(DE-2719)2812671$$aAntignano, Ignazio$$b21
000258661 7001_ $$aSivri, Burcu$$b22
000258661 7001_ $$aLu, Wenying$$b23
000258661 7001_ $$aEapen, Mathew S$$b24
000258661 7001_ $$0P:(DE-2719)9002579$$avan Uelft, Martina$$b25
000258661 7001_ $$0P:(DE-2719)2813660$$aOsei-Sarpong, Collins$$b26
000258661 7001_ $$avan den Berge, Maarten$$b27
000258661 7001_ $$aDonker, Hylke C$$b28
000258661 7001_ $$aGroen, Harry J M$$b29
000258661 7001_ $$aSohal, Sukhwinder S$$b30
000258661 7001_ $$aKlein, Johanna$$b31
000258661 7001_ $$aSchreiber, Tina$$b32
000258661 7001_ $$aFeißt, Andreas$$b33
000258661 7001_ $$aYildirim, Ali Önder$$b34
000258661 7001_ $$aSchiller, Herbert B$$b35
000258661 7001_ $$aNawijn, Martijn C$$b36
000258661 7001_ $$0P:(DE-2719)2812750$$aBecker, Matthias$$b37
000258661 7001_ $$0P:(DE-2719)2812735$$aHändler, Kristian$$b38
000258661 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc$$b39
000258661 7001_ $$0P:(DE-2719)2811780$$aCapasso, Melania$$b40
000258661 7001_ $$0P:(DE-2719)9000845$$aUlas, Thomas$$b41
000258661 7001_ $$aHasenauer, Jan$$b42
000258661 7001_ $$aPizarro, Carmen$$b43
000258661 7001_ $$aTheis, Fabian J$$b44
000258661 7001_ $$aHansbro, Philip M$$b45
000258661 7001_ $$aSkowasch, Dirk$$b46
000258661 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim$$b47
000258661 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2023.112525$$gVol. 42, no. 6, p. 112525 -$$n6$$p112525$$tCell reports$$v42$$x2211-1247$$y2023
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