TY  - JOUR
AU  - Kapellos, Theodore S
AU  - Baßler, Kevin
AU  - Fujii, Wataru
AU  - Nalkurthi, Christina
AU  - Schaar, Anna C
AU  - Bonaguro, Lorenzo
AU  - Pacht, Tal
AU  - Galvao, Izabela
AU  - Agrawal, Shobhit
AU  - Saglam, Adem
AU  - Dudkin, Erica
AU  - Frishberg, Amit
AU  - de Domenico, Elena
AU  - Horne, Arik
AU  - Donovan, Chantal
AU  - Kim, Richard Y
AU  - Gallego-Ortega, David
AU  - Gillett, Tessa E
AU  - Ansari, Meshal
AU  - Schulte-Schrepping, Jonas
AU  - Offermann, Nina
AU  - Antignano, Ignazio
AU  - Sivri, Burcu
AU  - Lu, Wenying
AU  - Eapen, Mathew S
AU  - van Uelft, Martina
AU  - Osei-Sarpong, Collins
AU  - van den Berge, Maarten
AU  - Donker, Hylke C
AU  - Groen, Harry J M
AU  - Sohal, Sukhwinder S
AU  - Klein, Johanna
AU  - Schreiber, Tina
AU  - Feißt, Andreas
AU  - Yildirim, Ali Önder
AU  - Schiller, Herbert B
AU  - Nawijn, Martijn C
AU  - Becker, Matthias
AU  - Händler, Kristian
AU  - Beyer, Marc
AU  - Capasso, Melania
AU  - Ulas, Thomas
AU  - Hasenauer, Jan
AU  - Pizarro, Carmen
AU  - Theis, Fabian J
AU  - Hansbro, Philip M
AU  - Skowasch, Dirk
AU  - Schultze, Joachim
TI  - Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease.
JO  - Cell reports
VL  - 42
IS  - 6
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - DZNE-2023-00634
SP  - 112525
PY  - 2023
AB  - Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (COPD) is a major respiratory disease characterized by small-airway inflammation, emphysema, and severe breathing difficulties. Using single-cell analyses we demonstrate that blood neutrophils are already increased in early-stage COPD, and changes in molecular and functional neutrophil states correlate with lung function decline. Assessing neutrophils and their bone marrow precursors in a murine cigarette smoke exposure model identified similar molecular changes in blood neutrophils and precursor populations that also occur in the blood and lung. Our study shows that systemic molecular alterations in neutrophils and their precursors are part of early-stage COPD, a finding to be further explored for potential therapeutic targets and biomarkers for early diagnosis and patient stratification.
KW  - Humans
KW  - Animals
KW  - Mice
KW  - Neutrophils
KW  - Pulmonary Disease, Chronic Obstructive: drug therapy
KW  - Lung
KW  - Pulmonary Emphysema
KW  - Inflammation
KW  - CP: Immunology (Other)
KW  - blood (Other)
KW  - bone marrow (Other)
KW  - chronic obstructive pulmonary disease (Other)
KW  - granulopoiesis (Other)
KW  - neutrophil (Other)
KW  - single-cell transcriptomics (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10320832
C6  - pmid:37243592
DO  - DOI:10.1016/j.celrep.2023.112525
UR  - https://pub.dzne.de/record/258661
ER  -