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@ARTICLE{Kapellos:258661,
      author       = {Kapellos, Theodore S and Baßler, Kevin and Fujii, Wataru
                      and Nalkurthi, Christina and Schaar, Anna C and Bonaguro,
                      Lorenzo and Pacht, Tal and Galvao, Izabela and Agrawal,
                      Shobhit and Saglam, Adem and Dudkin, Erica and Frishberg,
                      Amit and de Domenico, Elena and Horne, Arik and Donovan,
                      Chantal and Kim, Richard Y and Gallego-Ortega, David and
                      Gillett, Tessa E and Ansari, Meshal and Schulte-Schrepping,
                      Jonas and Offermann, Nina and Antignano, Ignazio and Sivri,
                      Burcu and Lu, Wenying and Eapen, Mathew S and van Uelft,
                      Martina and Osei-Sarpong, Collins and van den Berge, Maarten
                      and Donker, Hylke C and Groen, Harry J M and Sohal,
                      Sukhwinder S and Klein, Johanna and Schreiber, Tina and
                      Feißt, Andreas and Yildirim, Ali Önder and Schiller,
                      Herbert B and Nawijn, Martijn C and Becker, Matthias and
                      Händler, Kristian and Beyer, Marc and Capasso, Melania and
                      Ulas, Thomas and Hasenauer, Jan and Pizarro, Carmen and
                      Theis, Fabian J and Hansbro, Philip M and Skowasch, Dirk and
                      Schultze, Joachim},
      title        = {{S}ystemic alterations in neutrophils and their precursors
                      in early-stage chronic obstructive pulmonary disease.},
      journal      = {Cell reports},
      volume       = {42},
      number       = {6},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2023-00634},
      pages        = {112525},
      year         = {2023},
      abstract     = {Systemic inflammation is established as part of late-stage
                      severe lung disease, but molecular, functional, and
                      phenotypic changes in peripheral immune cells in early
                      disease stages remain ill defined. Chronic obstructive
                      pulmonary disease (COPD) is a major respiratory disease
                      characterized by small-airway inflammation, emphysema, and
                      severe breathing difficulties. Using single-cell analyses we
                      demonstrate that blood neutrophils are already increased in
                      early-stage COPD, and changes in molecular and functional
                      neutrophil states correlate with lung function decline.
                      Assessing neutrophils and their bone marrow precursors in a
                      murine cigarette smoke exposure model identified similar
                      molecular changes in blood neutrophils and precursor
                      populations that also occur in the blood and lung. Our study
                      shows that systemic molecular alterations in neutrophils and
                      their precursors are part of early-stage COPD, a finding to
                      be further explored for potential therapeutic targets and
                      biomarkers for early diagnosis and patient stratification.},
      keywords     = {Humans / Animals / Mice / Neutrophils / Pulmonary Disease,
                      Chronic Obstructive: drug therapy / Lung / Pulmonary
                      Emphysema / Inflammation / CP: Immunology (Other) / blood
                      (Other) / bone marrow (Other) / chronic obstructive
                      pulmonary disease (Other) / granulopoiesis (Other) /
                      neutrophil (Other) / single-cell transcriptomics (Other)},
      cin          = {Schultze - PRECISE / AG Capasso / AG Beyer / AG Becker},
      ddc          = {610},
      cid          = {I:(DE-2719)1013031 / I:(DE-2719)1013033 /
                      I:(DE-2719)1013035 / I:(DE-2719)5000079},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351) / 354 - Disease Prevention and Healthy Aging
                      (POF4-354)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-351 /
                      G:(DE-HGF)POF4-354},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10320832},
      pubmed       = {pmid:37243592},
      doi          = {10.1016/j.celrep.2023.112525},
      url          = {https://pub.dzne.de/record/258661},
}