%0 Journal Article
%A Fodder, Katherine
%A Murthy, Megha
%A Rizzu, Patrizia
%A Toomey, Christina E
%A Hasan, Rahat
%A Humphrey, Jack
%A Raj, Towfique
%A Lunnon, Katie
%A Mill, Jonathan
%A Heutink, Peter
%A Lashley, Tammaryn
%A Bettencourt, Conceição
%T Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.
%J Acta neuropathologica
%V 146
%N 1
%@ 0001-6322
%C Heidelberg
%I Springer
%M DZNE-2023-00652
%P 77 - 95
%D 2023
%X Frontotemporal lobar degeneration (FTLD) is an umbrella term describing the neuropathology of a clinically, genetically and pathologically heterogeneous group of diseases, including frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP). Among the major FTLD pathological subgroups, FTLD with TDP-43 positive inclusions (FTLD-TDP) and FTLD with tau-positive inclusions (FTLD-tau) are the most common, representing about 90
%K Humans
%K Frontotemporal Dementia: pathology
%K Frontotemporal Lobar Degeneration: pathology
%K Brain: pathology
%K Pick Disease of the Brain: pathology
%K DNA
%K tau Proteins: metabolism
%K Ubiquitin-Specific Proteases: metabolism
%K Co-methylation (Other)
%K DNA methylation (Other)
%K EWAS (Other)
%K Frontotemporal dementia (Other)
%K Human brain tissue (Other)
%K Progressive supranuclear palsy (Other)
%K DNA (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K OTUD4 protein, human (NLM Chemicals)
%K Ubiquitin-Specific Proteases (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37149835
%2 pmc:PMC10261190
%R 10.1007/s00401-023-02583-z
%U https://pub.dzne.de/record/258679