TY  - JOUR
AU  - Fodder, Katherine
AU  - Murthy, Megha
AU  - Rizzu, Patrizia
AU  - Toomey, Christina E
AU  - Hasan, Rahat
AU  - Humphrey, Jack
AU  - Raj, Towfique
AU  - Lunnon, Katie
AU  - Mill, Jonathan
AU  - Heutink, Peter
AU  - Lashley, Tammaryn
AU  - Bettencourt, Conceição
TI  - Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes.
JO  - Acta neuropathologica
VL  - 146
IS  - 1
SN  - 0001-6322
CY  - Heidelberg
PB  - Springer
M1  - DZNE-2023-00652
SP  - 77 - 95
PY  - 2023
AB  - Frontotemporal lobar degeneration (FTLD) is an umbrella term describing the neuropathology of a clinically, genetically and pathologically heterogeneous group of diseases, including frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP). Among the major FTLD pathological subgroups, FTLD with TDP-43 positive inclusions (FTLD-TDP) and FTLD with tau-positive inclusions (FTLD-tau) are the most common, representing about 90
KW  - Humans
KW  - Frontotemporal Dementia: pathology
KW  - Frontotemporal Lobar Degeneration: pathology
KW  - Brain: pathology
KW  - Pick Disease of the Brain: pathology
KW  - DNA
KW  - tau Proteins: metabolism
KW  - Ubiquitin-Specific Proteases: metabolism
KW  - Co-methylation (Other)
KW  - DNA methylation (Other)
KW  - EWAS (Other)
KW  - Frontotemporal dementia (Other)
KW  - Human brain tissue (Other)
KW  - Progressive supranuclear palsy (Other)
KW  - DNA (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - OTUD4 protein, human (NLM Chemicals)
KW  - Ubiquitin-Specific Proteases (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37149835
C2  - pmc:PMC10261190
DO  - DOI:10.1007/s00401-023-02583-z
UR  - https://pub.dzne.de/record/258679
ER  -