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000258684 0247_ $$2doi$$a10.1002/alz.13020
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000258684 1001_ $$aKloske, Courtney M$$b0
000258684 245__ $$aAPOE and immunity: Research highlights.
000258684 260__ $$aHoboken, NJ$$bWiley$$c2023
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000258684 520__ $$aAt the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
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000258684 650_7 $$2Other$$aAPOE
000258684 650_7 $$2Other$$aAlzheimer's disease
000258684 650_7 $$2Other$$aTREM2
000258684 650_7 $$2Other$$aamyloid beta
000258684 650_7 $$2Other$$aastrocytes
000258684 650_7 $$2Other$$abiomarkers
000258684 650_7 $$2Other$$adementia
000258684 650_7 $$2Other$$ainflammation
000258684 650_7 $$2Other$$amicroglia
000258684 650_7 $$2Other$$aneurodegeneration
000258684 650_7 $$2Other$$aneuroglia
000258684 650_7 $$2Other$$aneuroinflammation
000258684 650_7 $$2Other$$atau
000258684 650_7 $$2NLM Chemicals$$aApolipoproteins E
000258684 650_2 $$2MeSH$$aHumans
000258684 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000258684 650_2 $$2MeSH$$aMicroglia: pathology
000258684 650_2 $$2MeSH$$aInflammation
000258684 650_2 $$2MeSH$$aApolipoproteins E: genetics
000258684 7001_ $$aBarnum, Christopher J$$b1
000258684 7001_ $$aBatista, Andre F$$b2
000258684 7001_ $$aBradshaw, Elizabeth M$$b3
000258684 7001_ $$aBrickman, Adam M$$b4
000258684 7001_ $$aBu, Guojun$$b5
000258684 7001_ $$aDennison, Jessica$$b6
000258684 7001_ $$aGearon, Mary D$$b7
000258684 7001_ $$aGoate, Alison M$$b8
000258684 7001_ $$0P:(DE-2719)2202037$$aHaass, Christian$$b9$$udzne
000258684 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b10$$udzne
000258684 7001_ $$aHu, William T$$b11
000258684 7001_ $$aHuggins, Lenique K L$$b12
000258684 7001_ $$aJones, Nahdia S$$b13
000258684 7001_ $$aKoldamova, Radosveta$$b14
000258684 7001_ $$aLemere, Cynthia A$$b15
000258684 7001_ $$aLiddelow, Shane A$$b16
000258684 7001_ $$aMarcora, Edoardo$$b17
000258684 7001_ $$aMarsh, Samuel E$$b18
000258684 7001_ $$aNielsen, Henrietta M$$b19
000258684 7001_ $$aPetersen, Kellen K$$b20
000258684 7001_ $$aPetersen, Melissa$$b21
000258684 7001_ $$aPiña-Escudero, Stefanie D$$b22
000258684 7001_ $$aQiu, Wei Qiao$$b23
000258684 7001_ $$aQuiroz, Yakeel T$$b24
000258684 7001_ $$aReiman, Eric$$b25
000258684 7001_ $$00000-0002-3846-2986$$aSexton, Claire$$b26
000258684 7001_ $$aTansey, Malú Gámez$$b27
000258684 7001_ $$aTcw, Julia$$b28
000258684 7001_ $$aTeunissen, Charlotte E$$b29
000258684 7001_ $$aTijms, Betty M$$b30
000258684 7001_ $$avan der Kant, Rik$$b31
000258684 7001_ $$aWallings, Rebecca$$b32
000258684 7001_ $$aWeninger, Stacie C$$b33
000258684 7001_ $$aWharton, Whitney$$b34
000258684 7001_ $$aWilcock, Donna M$$b35
000258684 7001_ $$aWishard, Tyler James$$b36
000258684 7001_ $$aWorley, Susan L$$b37
000258684 7001_ $$aZetterberg, Henrik$$b38
000258684 7001_ $$aCarrillo, Maria C$$b39
000258684 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.13020$$gVol. 19, no. 6, p. 2677 - 2696$$n6$$p2677 - 2696$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
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