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000258690 1001_ $$0P:(DE-2719)2811945$$aJiang, Xueyan$$b0$$eFirst author
000258690 245__ $$aAltered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts.
000258690 260__ $$aHoboken, NJ$$bWiley$$c2023
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000258690 520__ $$aIt remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated with an amyloid burden.Cross-sectional resting-state functional magnetic resonance imaging connectivity (FC) and amyloid-positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.Limbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD-plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC-amyloid associations across cohorts.Our results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture-specific features to enrich preclinical Alzheimer's disease in non-Western populations.Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed. Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load. Further cross-cultural harmonization of SCD regarding Alzheimer's disease pathology is required.
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000258690 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000258690 650_7 $$2Other$$aCentiloid
000258690 650_7 $$2Other$$aamyloid deposition
000258690 650_7 $$2Other$$across-cultural harmonization
000258690 650_7 $$2Other$$afunctional connectivity
000258690 650_7 $$2Other$$ahippocampus
000258690 650_7 $$2Other$$ainsula
000258690 650_7 $$2Other$$asubjective cognitive decline
000258690 650_2 $$2MeSH$$aEuropean People
000258690 650_2 $$2MeSH$$aHumans
000258690 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000258690 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000258690 650_2 $$2MeSH$$aBrain: pathology
000258690 650_2 $$2MeSH$$aCognitive Dysfunction
000258690 650_2 $$2MeSH$$aCross-Sectional Studies
000258690 650_2 $$2MeSH$$aEast Asian People
000258690 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000258690 650_2 $$2MeSH$$aPositron-Emission Tomography
000258690 7001_ $$00000-0003-4126-673X$$aHu, Xiaochen$$b1
000258690 7001_ $$0P:(DE-2719)2811028$$aDaamen, Marcel$$b2
000258690 7001_ $$aWang, Xiaoqi$$b3
000258690 7001_ $$aFan, Chunqiu$$b4
000258690 7001_ $$0P:(DE-2719)9000940$$aMeiberth, Dix$$b5
000258690 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b6
000258690 7001_ $$0P:(DE-2719)2810395$$aRoeske, Sandra$$b7
000258690 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b8
000258690 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b9
000258690 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b10
000258690 7001_ $$0P:(DE-2719)2811189$$aLohse, Andrea$$b11
000258690 7001_ $$aHansen, Niels$$b12
000258690 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b13
000258690 7001_ $$0P:(DE-2719)9001517$$aIncesoy, Enise$$b14
000258690 7001_ $$0P:(DE-2719)2811611$$aDobisch, Laura$$b15
000258690 7001_ $$0P:(DE-2719)9002557$$aJanowitz, Daniel$$b16
000258690 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b17
000258690 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b18
000258690 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b19
000258690 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias$$b20
000258690 7001_ $$aWang, Xiao$$b21
000258690 7001_ $$0P:(DE-HGF)0$$aSchneider, Luisa-Sophie$$b22
000258690 7001_ $$0P:(DE-2719)9000554$$aGabelin, Tatjana$$b23
000258690 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b24
000258690 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b25
000258690 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b26
000258690 7001_ $$00000-0002-1773-1518$$aHetzer, Stefan$$b27
000258690 7001_ $$aDechent, Peter$$b28
000258690 7001_ $$0P:(DE-2719)9000543$$aEwers, Michael$$b29
000258690 7001_ $$00000-0001-6316-8773$$aScheffler, Klaus$$b30
000258690 7001_ $$00000-0003-4414-0657$$aAmthauer, Holger$$b31
000258690 7001_ $$00000-0002-0945-0724$$aBuchert, Ralph$$b32
000258690 7001_ $$aEssler, Markus$$b33
000258690 7001_ $$0P:(DE-2719)2811239$$aDrzezga, Alexander$$b34
000258690 7001_ $$0P:(DE-HGF)0$$aRominger, Axel$$b35
000258690 7001_ $$00000-0002-2572-4131$$aKrause, Bernd J$$b36
000258690 7001_ $$aReimold, Matthias$$b37
000258690 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b38
000258690 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b39
000258690 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b40
000258690 7001_ $$0P:(DE-2719)2811351$$aBuerger, Katharina$$b41
000258690 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b42
000258690 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b43
000258690 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b44
000258690 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b45
000258690 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b46
000258690 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b47
000258690 7001_ $$00000-0003-4948-3683$$aJiang, Jiehui$$b48
000258690 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b49
000258690 7001_ $$0P:(DE-2719)2810726$$aBoecker, Henning$$b50
000258690 7001_ $$00000-0003-0377-7424$$aHan, Ying$$b51
000258690 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.13068$$gp. alz.13068$$n11$$p4922 - 4934$$tAlzheimer's and dementia$$v19$$x1552-5260$$y2023
000258690 8564_ $$uhttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13068
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