TY  - JOUR
AU  - Jiang, Xueyan
AU  - Hu, Xiaochen
AU  - Daamen, Marcel
AU  - Wang, Xiaoqi
AU  - Fan, Chunqiu
AU  - Meiberth, Dix
AU  - Spottke, Annika
AU  - Roeske, Sandra
AU  - Fliessbach, Klaus
AU  - Spruth, Eike Jakob
AU  - Altenstein, Slawek
AU  - Lohse, Andrea
AU  - Hansen, Niels
AU  - Glanz, Wenzel
AU  - Incesoy, Enise
AU  - Dobisch, Laura
AU  - Janowitz, Daniel
AU  - Rauchmann, Boris Stephan
AU  - Ramirez, Alfredo
AU  - Kilimann, Ingo
AU  - Munk, Matthias
AU  - Wang, Xiao
AU  - Schneider, Luisa-Sophie
AU  - Gabelin, Tatjana
AU  - Roy, Nina
AU  - Wolfsgruber, Steffen
AU  - Kleineidam, Luca
AU  - Hetzer, Stefan
AU  - Dechent, Peter
AU  - Ewers, Michael
AU  - Scheffler, Klaus
AU  - Amthauer, Holger
AU  - Buchert, Ralph
AU  - Essler, Markus
AU  - Drzezga, Alexander
AU  - Rominger, Axel
AU  - Krause, Bernd J
AU  - Reimold, Matthias
AU  - Priller, Josef
AU  - Schneider, Anja
AU  - Wiltfang, Jens
AU  - Buerger, Katharina
AU  - Perneczky, Robert
AU  - Teipel, Stefan
AU  - Laske, Christoph
AU  - Peters, Oliver
AU  - Düzel, Emrah
AU  - Wagner, Michael
AU  - Jiang, Jiehui
AU  - Jessen, Frank
AU  - Boecker, Henning
AU  - Han, Ying
TI  - Altered limbic functional connectivity in individuals with subjective cognitive decline: Converging and diverging findings across Chinese and German cohorts.
JO  - Alzheimer's and dementia
VL  - 19
IS  - 11
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2023-00663
SP  - 4922 - 4934
PY  - 2023
AB  - It remains unclear whether functional brain networks are consistently altered in individuals with subjective cognitive decline (SCD) of diverse ethnic and cultural backgrounds and whether the network alterations are associated with an amyloid burden.Cross-sectional resting-state functional magnetic resonance imaging connectivity (FC) and amyloid-positron emission tomography (PET) data from the Chinese Sino Longitudinal Study on Cognitive Decline and German DZNE Longitudinal Cognitive Impairment and Dementia cohorts were analyzed.Limbic FC, particularly hippocampal connectivity with right insula, was consistently higher in SCD than in controls, and correlated with SCD-plus features. Smaller SCD subcohorts with PET showed inconsistent amyloid positivity rates and FC-amyloid associations across cohorts.Our results suggest an early adaptation of the limbic network in SCD, which may reflect increased awareness of cognitive decline, irrespective of amyloid pathology. Different amyloid positivity rates may indicate a heterogeneous underlying etiology in Eastern and Western SCD cohorts when applying current research criteria. Future studies should identify culture-specific features to enrich preclinical Alzheimer's disease in non-Western populations.Common limbic hyperconnectivity across Chinese and German subjective cognitive decline (SCD) cohorts was observed. Limbic hyperconnectivity may reflect awareness of cognition, irrespective of amyloid load. Further cross-cultural harmonization of SCD regarding Alzheimer's disease pathology is required.
KW  - European People
KW  - Humans
KW  - Alzheimer Disease: pathology
KW  - Amyloid beta-Peptides: metabolism
KW  - Brain: pathology
KW  - Cognitive Dysfunction
KW  - Cross-Sectional Studies
KW  - East Asian People
KW  - Magnetic Resonance Imaging
KW  - Positron-Emission Tomography
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Centiloid (Other)
KW  - amyloid deposition (Other)
KW  - cross-cultural harmonization (Other)
KW  - functional connectivity (Other)
KW  - hippocampus (Other)
KW  - insula (Other)
KW  - subjective cognitive decline (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37070734
DO  - DOI:10.1002/alz.13068
UR  - https://pub.dzne.de/record/258690
ER  -