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000258691 037__ $$aDZNE-2023-00664
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000258691 1001_ $$0P:(DE-2719)9001992$$aFavila, Natalia$$b0$$eFirst author$$udzne
000258691 245__ $$aThe NK1 antagonist L-733,060 facilitates sequence learning.
000258691 260__ $$aLondon [u.a.]$$bSage$$c2023
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000258691 520__ $$aAlthough several brain regions and electrophysiological patterns have been related to sequence learning, less attention has been paid to the role that different neuromodulators play.Here we sought to investigate the role of substance P (SP) in sequence learning in an operant conditioning preparation, supported by a reinforcement learning model.Two experiments were performed to test the effects of an NK1 receptor (at which SP primarily acts) antagonist on learning and performing action sequences. In experiment 1, rats were trained to perform an action sequence until stable performance was achieved, and then, in phase 2, they were switched to perform the reverse sequence. In experiment 2, rats were trained to perform an action sequence, and in phase 2, they continued to do the same sequence. In both experiments in the first 3 days of phase 2, rats were injected with an NK1 receptor antagonist (L-733,060, i.p.) or with vehicle. Additionally, we developed a reinforcement learning model which allowed the in silico replication of our experimental tasks.We found that administering an NK1 receptor antagonist weakened the stable retention of a well-learned sequence, allowing the faster acquisition of a new sequence, without impairing the continued performance of a crystallized sequence. Using our reinforcement learning model, we suggest that SP could be acting through the state value learning rate, modulating the effects of the reward prediction error.Our results suggest that SP could be involved in the consolidation of a sequence representation through a modulatory effect on the reward prediction error.
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000258691 650_2 $$2MeSH$$aRats
000258691 650_2 $$2MeSH$$aAnimals
000258691 650_2 $$2MeSH$$aLearning
000258691 650_2 $$2MeSH$$aReinforcement, Psychology
000258691 650_2 $$2MeSH$$aPiperidines: pharmacology
000258691 650_2 $$2MeSH$$aConditioning, Operant
000258691 650_2 $$2MeSH$$aReward
000258691 650_2 $$2MeSH$$aSubstance P: pharmacology
000258691 650_2 $$2MeSH$$aReceptors, Neurokinin-1
000258691 650_7 $$0148700-85-0$$2NLM Chemicals$$a3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine
000258691 650_7 $$2Other$$aAction sequences
000258691 650_7 $$2Other$$areinforcement learning
000258691 650_7 $$2Other$$areward prediction error
000258691 650_7 $$2Other$$astriosomes
000258691 650_7 $$2Other$$asubstance P
000258691 650_7 $$2NLM Chemicals$$aPiperidines
000258691 650_7 $$033507-63-0$$2NLM Chemicals$$aSubstance P
000258691 650_7 $$2NLM Chemicals$$aReceptors, Neurokinin-1
000258691 7001_ $$aGurney, Kevin$$b1
000258691 7001_ $$aOverton, Paul G$$b2
000258691 773__ $$0PERI:(DE-600)2028926-1$$a10.1177/02698811231161582$$gp. 026988112311615 -$$n6$$p610-626$$tJournal of psychopharmacology$$v37$$x0269-8811$$y2023
000258691 8564_ $$uhttps://journals.sagepub.com/doi/10.1177/02698811231161582
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