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@ARTICLE{Favila:258691,
      author       = {Favila, Natalia and Gurney, Kevin and Overton, Paul G},
      title        = {{T}he {NK}1 antagonist {L}-733,060 facilitates sequence
                      learning.},
      journal      = {Journal of psychopharmacology},
      volume       = {37},
      number       = {6},
      issn         = {0269-8811},
      address      = {London [u.a.]},
      publisher    = {Sage},
      reportid     = {DZNE-2023-00664},
      pages        = {610-626},
      year         = {2023},
      abstract     = {Although several brain regions and electrophysiological
                      patterns have been related to sequence learning, less
                      attention has been paid to the role that different
                      neuromodulators play.Here we sought to investigate the role
                      of substance P (SP) in sequence learning in an operant
                      conditioning preparation, supported by a reinforcement
                      learning model.Two experiments were performed to test the
                      effects of an NK1 receptor (at which SP primarily acts)
                      antagonist on learning and performing action sequences. In
                      experiment 1, rats were trained to perform an action
                      sequence until stable performance was achieved, and then, in
                      phase 2, they were switched to perform the reverse sequence.
                      In experiment 2, rats were trained to perform an action
                      sequence, and in phase 2, they continued to do the same
                      sequence. In both experiments in the first 3 days of phase
                      2, rats were injected with an NK1 receptor antagonist
                      (L-733,060, i.p.) or with vehicle. Additionally, we
                      developed a reinforcement learning model which allowed the
                      in silico replication of our experimental tasks.We found
                      that administering an NK1 receptor antagonist weakened the
                      stable retention of a well-learned sequence, allowing the
                      faster acquisition of a new sequence, without impairing the
                      continued performance of a crystallized sequence. Using our
                      reinforcement learning model, we suggest that SP could be
                      acting through the state value learning rate, modulating the
                      effects of the reward prediction error.Our results suggest
                      that SP could be involved in the consolidation of a sequence
                      representation through a modulatory effect on the reward
                      prediction error.},
      keywords     = {Rats / Animals / Learning / Reinforcement, Psychology /
                      Piperidines: pharmacology / Conditioning, Operant / Reward /
                      Substance P: pharmacology / Receptors, Neurokinin-1 /
                      3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine
                      (NLM Chemicals) / Action sequences (Other) / reinforcement
                      learning (Other) / reward prediction error (Other) /
                      striosomes (Other) / substance P (Other) / Piperidines (NLM
                      Chemicals) / Substance P (NLM Chemicals) / Receptors,
                      Neurokinin-1 (NLM Chemicals)},
      cin          = {AG Krabbe ; AG Krabbe},
      ddc          = {610},
      cid          = {I:(DE-2719)5000059},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10291388},
      pubmed       = {pmid:36988219},
      doi          = {10.1177/02698811231161582},
      url          = {https://pub.dzne.de/record/258691},
}