000258694 001__ 258694
000258694 005__ 20240808173022.0
000258694 0247_ $$2pmc$$apmc:PMC10544694
000258694 0247_ $$2doi$$a10.1007/s12311-023-01546-0
000258694 0247_ $$2pmid$$apmid:37002505
000258694 0247_ $$2ISSN$$a1473-4222
000258694 0247_ $$2ISSN$$a1473-4230
000258694 0247_ $$2altmetric$$aaltmetric:144831525
000258694 037__ $$aDZNE-2023-00667
000258694 041__ $$aEnglish
000258694 082__ $$a610
000258694 1001_ $$aUebachs, Mischa$$b0
000258694 245__ $$aSCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias.
000258694 260__ $$aLondon$$bDunitz$$c2024
000258694 3367_ $$2DRIVER$$aarticle
000258694 3367_ $$2DataCite$$aOutput Types/Journal article
000258694 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1716276858_21513
000258694 3367_ $$2BibTeX$$aARTICLE
000258694 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000258694 3367_ $$00$$2EndNote$$aJournal Article
000258694 520__ $$aWith SCAview, we present a prompt and comprehensive tool that enables scientists to browse large datasets of the most common spinocerebellar ataxias intuitively and without technical effort. Basic concept is a visualization of data, with a graphical handling and filtering to select and define subgroups and their comparison. Several plot types to visualize all data points resulting from the selected attributes are provided. The underlying synthetic cohort is based on clinical data from five different European and US longitudinal multicenter cohorts in spinocerebellar ataxia type 1, 2, 3, and 6 (SCA1, 2, 3, and 6) comprising > 1400 patients with overall > 5500 visits. First, we developed a common data model to integrate the clinical, demographic, and characterizing data of each source cohort. Second, the available datasets from each cohort were mapped onto the data model. Third, we created a synthetic cohort based on the cleaned dataset. With SCAview, we demonstrate the feasibility of mapping cohort data from different sources onto a common data model. The resulting browser-based visualization tool with a thoroughly graphical handling of the data offers researchers the unique possibility to visualize relationships and distributions of clinical data, to define subgroups and to further investigate them without any technical effort. Access to SCAview can be requested via the Ataxia Global Initiative and is free of charge.
000258694 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000258694 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000258694 650_7 $$2Other$$aObservational studies
000258694 650_7 $$2Other$$aSpinocerebellar ataxia (SCA)
000258694 650_7 $$2Other$$aVisualization
000258694 650_2 $$2MeSH$$aHumans
000258694 650_2 $$2MeSH$$aSpinocerebellar Ataxias: genetics
000258694 650_2 $$2MeSH$$aCohort Studies
000258694 650_2 $$2MeSH$$aSoftware
000258694 7001_ $$0P:(DE-2719)9002349$$aWegner, Philipp$$b1
000258694 7001_ $$aSchaaf, Sebastian$$b2
000258694 7001_ $$aKugai, Simon$$b3
000258694 7001_ $$0P:(DE-2719)2811564$$aJacobi, Heike$$b4
000258694 7001_ $$aKuo, Sheng-Han$$b5
000258694 7001_ $$aAshizawa, Tetsuo$$b6
000258694 7001_ $$aFluck, Juliane$$b7
000258694 7001_ $$agroup, EUROSCA study$$b8$$eCollaboration Author
000258694 7001_ $$agroup, ESMI study$$b9$$eCollaboration Author
000258694 7001_ $$agroup, RISCA study$$b10$$eCollaboration Author
000258694 7001_ $$agroup, CRC-SCA study$$b11$$eCollaboration Author
000258694 7001_ $$agroup, SCA Registry study$$b12$$eCollaboration Author
000258694 7001_ $$0P:(DE-2719)2810314$$aKlockgether, Thomas$$b13
000258694 7001_ $$0P:(DE-2719)2811327$$aFaber, Jennifer$$b14$$eLast author
000258694 7001_ $$adu Montcel, Sophie Tezenas$$b15$$eContributor
000258694 7001_ $$aBauer, Peter$$b16$$eContributor
000258694 7001_ $$aGiunti, Paola$$b17$$eContributor
000258694 7001_ $$aCook, Arron$$b18$$eContributor
000258694 7001_ $$aLabrum, Robyn$$b19$$eContributor
000258694 7001_ $$aParkinson, Michael H$$b20$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aDurr, Alexandra$$b21$$eContributor
000258694 7001_ $$aBrice, Alexis$$b22$$eContributor
000258694 7001_ $$aCharles, Perrine$$b23$$eContributor
000258694 7001_ $$aMarelli, Cecilia$$b24$$eContributor
000258694 7001_ $$aMariotti, Caterina$$b25$$eContributor
000258694 7001_ $$aNanetti, Lorenzo$$b26$$eContributor
000258694 7001_ $$aPanzeri, Marta$$b27$$eContributor
000258694 7001_ $$aRakowicz, Maria$$b28$$eContributor
000258694 7001_ $$aSulek, Anna$$b29$$eContributor
000258694 7001_ $$aSobanska, Anna$$b30$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aSchmitz-Hübsch, Tanja$$b31$$eContributor
000258694 7001_ $$0P:(DE-2719)2810795$$aSchöls, Ludger$$b32$$eContributor$$udzne
000258694 7001_ $$0P:(DE-2719)2811940$$aHengel, Holger$$b33$$eContributor$$udzne
000258694 7001_ $$aBaliko, Laszlo$$b34$$eContributor
000258694 7001_ $$aMelegh, Bela$$b35$$eContributor
000258694 7001_ $$aFilla, Alessandro$$b36$$eContributor
000258694 7001_ $$aAntenora, Antonella$$b37$$eContributor
000258694 7001_ $$aInfante, Jon$$b38$$eContributor
000258694 7001_ $$aBerciano, José$$b39$$eContributor
000258694 7001_ $$avan de Warrenburg, Bart P$$b40$$eContributor
000258694 7001_ $$aTimmann, Dagmar$$b41$$eContributor
000258694 7001_ $$aSzymanski, Sandra$$b42$$eContributor
000258694 7001_ $$aBoesch, Sylvia$$b43$$eContributor
000258694 7001_ $$aKang, Jun-Suk$$b44$$eContributor
000258694 7001_ $$aPandolfo, Massimo$$b45$$eContributor
000258694 7001_ $$aSchulz, Jörg B$$b46$$eContributor
000258694 7001_ $$aMolho, Sonia$$b47$$eContributor
000258694 7001_ $$aDiallo, Alhassane$$b48$$eContributor
000258694 7001_ $$0P:(DE-2719)9001510$$aGrobe-Einsler, Marcus$$b49$$eContributor$$udzne
000258694 7001_ $$aÖnder, Demet$$b50$$eContributor
000258694 7001_ $$aRaposo, Mafalda$$b51$$eContributor
000258694 7001_ $$aVasconcelos, João$$b52$$eContributor
000258694 7001_ $$aLima, Manuela$$b53$$eContributor
000258694 7001_ $$ade Almeida, Luís Pereira$$b54$$eContributor
000258694 7001_ $$aSilva, Patrick$$b55$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aCunha, Inês$$b56$$eContributor
000258694 7001_ $$aGiunti, Paola$$b57$$eContributor
000258694 7001_ $$aGarcia-Moreno, Hector$$b58$$eContributor
000258694 7001_ $$aManso, Katarina$$b59$$eContributor
000258694 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b60$$eContributor$$udzne
000258694 7001_ $$0P:(DE-HGF)0$$aHengel, Holger$$b61$$eContributor
000258694 7001_ $$0P:(DE-2719)9000792$$aTraschuetz, Andreas$$b62$$eContributor$$udzne
000258694 7001_ $$avan de Warrenburg, Bart$$b63$$eContributor
000258694 7001_ $$avan Gaalen, Judith$$b64$$eContributor
000258694 7001_ $$aPerbolt, Tessa$$b65$$eContributor
000258694 7001_ $$aBushara, Khalaf$$b66$$eContributor
000258694 7001_ $$aHutter, Diane$$b67$$eContributor
000258694 7001_ $$aInfante, Jon$$b68$$eContributor
000258694 7001_ $$aManrique, Leire$$b69$$eContributor
000258694 7001_ $$aThieme, Andreas$$b70$$eContributor
000258694 7001_ $$aErdlenbruch, Friedrich$$b71$$eContributor
000258694 7001_ $$aOnyike, Chiadi$$b72$$eContributor
000258694 7001_ $$aFishman, Ann$$b73$$eContributor
000258694 7001_ $$aReetz, Kathrin$$b74$$eContributor
000258694 7001_ $$aDogan, Imis$$b75$$eContributor
000258694 7001_ $$aRatai, Eva$$b76$$eContributor
000258694 7001_ $$aSchmahmann, Jeremy$$b77$$eContributor
000258694 7001_ $$aSantana, Magda$$b78$$eContributor
000258694 7001_ $$aHübener-Schmid, Jeannette$$b79$$eContributor
000258694 7001_ $$adu Montcel, Sophie Tezenas$$b80$$eContributor
000258694 7001_ $$aRomanzetti, Sandro$$b81$$eContributor
000258694 7001_ $$aHarmuth, Florian$$b82$$eContributor
000258694 7001_ $$aMariotti, Caterina$$b83$$eContributor
000258694 7001_ $$aNanetti, Lorenzo$$b84$$eContributor
000258694 7001_ $$aRakowicz, Maria$$b85$$eContributor
000258694 7001_ $$aMakowicz, Grzegorz$$b86$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aDurr, Alexandra$$b87$$eContributor
000258694 7001_ $$aFilla, Alessandro$$b88$$eContributor
000258694 7001_ $$aRoca, Alessandro$$b89$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aSchöls, Ludger$$b90$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aHengel, Holger$$b91$$eContributor
000258694 7001_ $$aInfante, Jon$$b92$$eContributor
000258694 7001_ $$aKang, Jun-Suk$$b93$$eContributor
000258694 7001_ $$aCasalo, Carlo$$b94$$eContributor
000258694 7001_ $$aMasciullo, Marcella$$b95$$eContributor
000258694 7001_ $$aBaliko, Laszlo$$b96$$eContributor
000258694 7001_ $$aMelegh, Bela$$b97$$eContributor
000258694 7001_ $$aNachbauer, Wolfgang$$b98$$eContributor
000258694 7001_ $$aBürk-Gergs, Katrin$$b99$$eContributor
000258694 7001_ $$aSchulz, Jörg B$$b100$$eContributor
000258694 7001_ $$aRiess, Olaf$$b101$$eContributor
000258694 7001_ $$aReetz, Kathrin$$b102$$eContributor
000258694 7001_ $$aFigueroa, Karla P$$b103$$eContributor
000258694 7001_ $$aPerlman, Susan L$$b104$$eContributor
000258694 7001_ $$aGomez, Christopher M$$b105$$eContributor
000258694 7001_ $$aWilmot, George R$$b106$$eContributor
000258694 7001_ $$aSchmahmann, Jeremy D$$b107$$eContributor
000258694 7001_ $$aYing, Sarah H$$b108$$eContributor
000258694 7001_ $$aZesiewicz, Theresa A$$b109$$eContributor
000258694 7001_ $$aPaulson, Henry L$$b110$$eContributor
000258694 7001_ $$aShakkottai, Vikram G$$b111$$eContributor
000258694 7001_ $$aBushara, Khalaf$$b112$$eContributor
000258694 7001_ $$aGeschwind, Michael D$$b113$$eContributor
000258694 7001_ $$aXia, Guangbin$$b114$$eContributor
000258694 7001_ $$aPulst, Stefan M$$b115$$eContributor
000258694 7001_ $$aSubramony, Sub H$$b116$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aGrobe-Einsler, Marcus$$b117$$eContributor
000258694 7001_ $$aÖnder, Demet$$b118$$eContributor
000258694 7001_ $$0P:(DE-HGF)0$$aKoyak, Berkan$$b119$$eContributor
000258694 7001_ $$aReetz, Kathrin$$b120$$eContributor
000258694 773__ $$0PERI:(DE-600)2071266-2$$a10.1007/s12311-023-01546-0$$n3$$p887 - 895$$tThe Cerebellum$$v23$$x1473-4222$$y2024
000258694 8564_ $$uhttps://link.springer.com/article/10.1007/s12311-023-01546-0
000258694 8564_ $$uhttps://pub.dzne.de/record/258694/files/DZNE-2023-00667.pdf$$yOpenAccess
000258694 8564_ $$uhttps://pub.dzne.de/record/258694/files/DZNE-2023-00667.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000258694 909CO $$ooai:pub.dzne.de:258694$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000258694 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002349$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000258694 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811564$$aExternal Institute$$b4$$kExtern
000258694 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810314$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000258694 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811327$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000258694 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2810795$$aExternal Institute$$b32$$kExtern
000258694 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811940$$aExternal Institute$$b33$$kExtern
000258694 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001510$$aExternal Institute$$b49$$kExtern
000258694 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2811275$$aExternal Institute$$b60$$kExtern
000258694 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000792$$aExternal Institute$$b62$$kExtern
000258694 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000258694 9141_ $$y2023
000258694 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-17
000258694 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000258694 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-17
000258694 915__ $$0StatID:(DE-HGF)3002$$2StatID$$aDEAL Springer$$d2022-11-17$$wger
000258694 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000258694 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-24
000258694 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-24
000258694 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-24
000258694 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-24
000258694 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCEREBELLUM : 2022$$d2023-08-24
000258694 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-24
000258694 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-24
000258694 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-24
000258694 9201_ $$0I:(DE-2719)1011101$$kPatient Studies Bonn$$lPatient Studies Bonn$$x0
000258694 9201_ $$0I:(DE-2719)1011401$$kClinical Research Platform (CRP)$$lClinical Research Platform (CRP)$$x1
000258694 9201_ $$0I:(DE-2719)1011001$$kAG Klockgether$$lPatient Studies$$x2
000258694 980__ $$ajournal
000258694 980__ $$aVDB
000258694 980__ $$aI:(DE-2719)1011101
000258694 980__ $$aI:(DE-2719)1011401
000258694 980__ $$aI:(DE-2719)1011001
000258694 980__ $$aUNRESTRICTED
000258694 9801_ $$aFullTexts