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@ARTICLE{Uebachs:258694,
      author       = {Uebachs, Mischa and Wegner, Philipp and Schaaf, Sebastian
                      and Kugai, Simon and Jacobi, Heike and Kuo, Sheng-Han and
                      Ashizawa, Tetsuo and Fluck, Juliane and Klockgether, Thomas
                      and Faber, Jennifer},
      collaboration = {group, EUROSCA study and group, ESMI study and group, RISCA
                      study and group, CRC-SCA study and group, SCA Registry
                      study},
      othercontributors = {du Montcel, Sophie Tezenas and Bauer, Peter and Giunti,
                          Paola and Cook, Arron and Labrum, Robyn and Parkinson,
                          Michael H and Durr, Alexandra and Brice, Alexis and Charles,
                          Perrine and Marelli, Cecilia and Mariotti, Caterina and
                          Nanetti, Lorenzo and Panzeri, Marta and Rakowicz, Maria and
                          Sulek, Anna and Sobanska, Anna and Schmitz-Hübsch, Tanja
                          and Schöls, Ludger and Hengel, Holger and Baliko, Laszlo
                          and Melegh, Bela and Filla, Alessandro and Antenora,
                          Antonella and Infante, Jon and Berciano, José and van de
                          Warrenburg, Bart P and Timmann, Dagmar and Szymanski, Sandra
                          and Boesch, Sylvia and Kang, Jun-Suk and Pandolfo, Massimo
                          and Schulz, Jörg B and Molho, Sonia and Diallo, Alhassane
                          and Grobe-Einsler, Marcus and Önder, Demet and Raposo,
                          Mafalda and Vasconcelos, João and Lima, Manuela and de
                          Almeida, Luís Pereira and Silva, Patrick and Cunha, Inês
                          and Giunti, Paola and Garcia-Moreno, Hector and Manso,
                          Katarina and Synofzik, Matthis and Hengel, Holger and
                          Traschuetz, Andreas and van de Warrenburg, Bart and van
                          Gaalen, Judith and Perbolt, Tessa and Bushara, Khalaf and
                          Hutter, Diane and Infante, Jon and Manrique, Leire and
                          Thieme, Andreas and Erdlenbruch, Friedrich and Onyike,
                          Chiadi and Fishman, Ann and Reetz, Kathrin and Dogan, Imis
                          and Ratai, Eva and Schmahmann, Jeremy and Santana, Magda and
                          Hübener-Schmid, Jeannette and du Montcel, Sophie Tezenas
                          and Romanzetti, Sandro and Harmuth, Florian and Mariotti,
                          Caterina and Nanetti, Lorenzo and Rakowicz, Maria and
                          Makowicz, Grzegorz and Durr, Alexandra and Filla, Alessandro
                          and Roca, Alessandro and Schöls, Ludger and Hengel, Holger
                          and Infante, Jon and Kang, Jun-Suk and Casalo, Carlo and
                          Masciullo, Marcella and Baliko, Laszlo and Melegh, Bela and
                          Nachbauer, Wolfgang and Bürk-Gergs, Katrin and Schulz,
                          Jörg B and Riess, Olaf and Reetz, Kathrin and Figueroa,
                          Karla P and Perlman, Susan L and Gomez, Christopher M and
                          Wilmot, George R and Schmahmann, Jeremy D and Ying, Sarah H
                          and Zesiewicz, Theresa A and Paulson, Henry L and
                          Shakkottai, Vikram G and Bushara, Khalaf and Geschwind,
                          Michael D and Xia, Guangbin and Pulst, Stefan M and
                          Subramony, Sub H and Grobe-Einsler, Marcus and Önder, Demet
                          and Koyak, Berkan and Reetz, Kathrin},
      title        = {{SCA}view: an {I}ntuitive {V}isual {A}pproach to the
                      {I}ntegrative {A}nalysis of {C}linical {D}ata in
                      {S}pinocerebellar {A}taxias.},
      journal      = {The Cerebellum},
      volume       = {23},
      number       = {3},
      issn         = {1473-4222},
      address      = {London},
      publisher    = {Dunitz},
      reportid     = {DZNE-2023-00667},
      pages        = {887 - 895},
      year         = {2024},
      abstract     = {With SCAview, we present a prompt and comprehensive tool
                      that enables scientists to browse large datasets of the most
                      common spinocerebellar ataxias intuitively and without
                      technical effort. Basic concept is a visualization of data,
                      with a graphical handling and filtering to select and define
                      subgroups and their comparison. Several plot types to
                      visualize all data points resulting from the selected
                      attributes are provided. The underlying synthetic cohort is
                      based on clinical data from five different European and US
                      longitudinal multicenter cohorts in spinocerebellar ataxia
                      type 1, 2, 3, and 6 (SCA1, 2, 3, and 6) comprising > 1400
                      patients with overall > 5500 visits. First, we developed a
                      common data model to integrate the clinical, demographic,
                      and characterizing data of each source cohort. Second, the
                      available datasets from each cohort were mapped onto the
                      data model. Third, we created a synthetic cohort based on
                      the cleaned dataset. With SCAview, we demonstrate the
                      feasibility of mapping cohort data from different sources
                      onto a common data model. The resulting browser-based
                      visualization tool with a thoroughly graphical handling of
                      the data offers researchers the unique possibility to
                      visualize relationships and distributions of clinical data,
                      to define subgroups and to further investigate them without
                      any technical effort. Access to SCAview can be requested via
                      the Ataxia Global Initiative and is free of charge.},
      keywords     = {Humans / Spinocerebellar Ataxias: genetics / Cohort Studies
                      / Software / Observational studies (Other) / Spinocerebellar
                      ataxia (SCA) (Other) / Visualization (Other)},
      cin          = {Patient Studies Bonn / Clinical Research Platform (CRP) /
                      AG Klockgether},
      ddc          = {610},
      cid          = {I:(DE-2719)1011101 / I:(DE-2719)1011401 /
                      I:(DE-2719)1011001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10544694},
      pubmed       = {pmid:37002505},
      doi          = {10.1007/s12311-023-01546-0},
      url          = {https://pub.dzne.de/record/258694},
}