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| Home > Publications Database > SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias. > print |
| 001 | 258694 | ||
| 005 | 20240808173022.0 | ||
| 024 | 7 | _ | |a pmc:PMC10544694 |2 pmc |
| 024 | 7 | _ | |a 10.1007/s12311-023-01546-0 |2 doi |
| 024 | 7 | _ | |a pmid:37002505 |2 pmid |
| 024 | 7 | _ | |a 1473-4222 |2 ISSN |
| 024 | 7 | _ | |a 1473-4230 |2 ISSN |
| 024 | 7 | _ | |a altmetric:144831525 |2 altmetric |
| 037 | _ | _ | |a DZNE-2023-00667 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Uebachs, Mischa |b 0 |
| 245 | _ | _ | |a SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias. |
| 260 | _ | _ | |a London |c 2024 |b Dunitz |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1716276858_21513 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a With SCAview, we present a prompt and comprehensive tool that enables scientists to browse large datasets of the most common spinocerebellar ataxias intuitively and without technical effort. Basic concept is a visualization of data, with a graphical handling and filtering to select and define subgroups and their comparison. Several plot types to visualize all data points resulting from the selected attributes are provided. The underlying synthetic cohort is based on clinical data from five different European and US longitudinal multicenter cohorts in spinocerebellar ataxia type 1, 2, 3, and 6 (SCA1, 2, 3, and 6) comprising > 1400 patients with overall > 5500 visits. First, we developed a common data model to integrate the clinical, demographic, and characterizing data of each source cohort. Second, the available datasets from each cohort were mapped onto the data model. Third, we created a synthetic cohort based on the cleaned dataset. With SCAview, we demonstrate the feasibility of mapping cohort data from different sources onto a common data model. The resulting browser-based visualization tool with a thoroughly graphical handling of the data offers researchers the unique possibility to visualize relationships and distributions of clinical data, to define subgroups and to further investigate them without any technical effort. Access to SCAview can be requested via the Ataxia Global Initiative and is free of charge. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Observational studies |2 Other |
| 650 | _ | 7 | |a Spinocerebellar ataxia (SCA) |2 Other |
| 650 | _ | 7 | |a Visualization |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Spinocerebellar Ataxias: genetics |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 650 | _ | 2 | |a Software |2 MeSH |
| 700 | 1 | _ | |a Wegner, Philipp |0 P:(DE-2719)9002349 |b 1 |
| 700 | 1 | _ | |a Schaaf, Sebastian |b 2 |
| 700 | 1 | _ | |a Kugai, Simon |b 3 |
| 700 | 1 | _ | |a Jacobi, Heike |0 P:(DE-2719)2811564 |b 4 |
| 700 | 1 | _ | |a Kuo, Sheng-Han |b 5 |
| 700 | 1 | _ | |a Ashizawa, Tetsuo |b 6 |
| 700 | 1 | _ | |a Fluck, Juliane |b 7 |
| 700 | 1 | _ | |a group, EUROSCA study |b 8 |e Collaboration Author |
| 700 | 1 | _ | |a group, ESMI study |b 9 |e Collaboration Author |
| 700 | 1 | _ | |a group, RISCA study |b 10 |e Collaboration Author |
| 700 | 1 | _ | |a group, CRC-SCA study |b 11 |e Collaboration Author |
| 700 | 1 | _ | |a group, SCA Registry study |b 12 |e Collaboration Author |
| 700 | 1 | _ | |a Klockgether, Thomas |0 P:(DE-2719)2810314 |b 13 |
| 700 | 1 | _ | |a Faber, Jennifer |0 P:(DE-2719)2811327 |b 14 |e Last author |
| 700 | 1 | _ | |a du Montcel, Sophie Tezenas |b 15 |e Contributor |
| 700 | 1 | _ | |a Bauer, Peter |b 16 |e Contributor |
| 700 | 1 | _ | |a Giunti, Paola |b 17 |e Contributor |
| 700 | 1 | _ | |a Cook, Arron |b 18 |e Contributor |
| 700 | 1 | _ | |a Labrum, Robyn |b 19 |e Contributor |
| 700 | 1 | _ | |a Parkinson, Michael H |b 20 |e Contributor |
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| 700 | 1 | _ | |a Brice, Alexis |b 22 |e Contributor |
| 700 | 1 | _ | |a Charles, Perrine |b 23 |e Contributor |
| 700 | 1 | _ | |a Marelli, Cecilia |b 24 |e Contributor |
| 700 | 1 | _ | |a Mariotti, Caterina |b 25 |e Contributor |
| 700 | 1 | _ | |a Nanetti, Lorenzo |b 26 |e Contributor |
| 700 | 1 | _ | |a Panzeri, Marta |b 27 |e Contributor |
| 700 | 1 | _ | |a Rakowicz, Maria |b 28 |e Contributor |
| 700 | 1 | _ | |a Sulek, Anna |b 29 |e Contributor |
| 700 | 1 | _ | |a Sobanska, Anna |b 30 |e Contributor |
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| 700 | 1 | _ | |a Infante, Jon |b 38 |e Contributor |
| 700 | 1 | _ | |a Berciano, José |b 39 |e Contributor |
| 700 | 1 | _ | |a van de Warrenburg, Bart P |b 40 |e Contributor |
| 700 | 1 | _ | |a Timmann, Dagmar |b 41 |e Contributor |
| 700 | 1 | _ | |a Szymanski, Sandra |b 42 |e Contributor |
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| 700 | 1 | _ | |a de Almeida, Luís Pereira |b 54 |e Contributor |
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| 700 | 1 | _ | |a van de Warrenburg, Bart |b 63 |e Contributor |
| 700 | 1 | _ | |a van Gaalen, Judith |b 64 |e Contributor |
| 700 | 1 | _ | |a Perbolt, Tessa |b 65 |e Contributor |
| 700 | 1 | _ | |a Bushara, Khalaf |b 66 |e Contributor |
| 700 | 1 | _ | |a Hutter, Diane |b 67 |e Contributor |
| 700 | 1 | _ | |a Infante, Jon |b 68 |e Contributor |
| 700 | 1 | _ | |a Manrique, Leire |b 69 |e Contributor |
| 700 | 1 | _ | |a Thieme, Andreas |b 70 |e Contributor |
| 700 | 1 | _ | |a Erdlenbruch, Friedrich |b 71 |e Contributor |
| 700 | 1 | _ | |a Onyike, Chiadi |b 72 |e Contributor |
| 700 | 1 | _ | |a Fishman, Ann |b 73 |e Contributor |
| 700 | 1 | _ | |a Reetz, Kathrin |b 74 |e Contributor |
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| 700 | 1 | _ | |a Figueroa, Karla P |b 103 |e Contributor |
| 700 | 1 | _ | |a Perlman, Susan L |b 104 |e Contributor |
| 700 | 1 | _ | |a Gomez, Christopher M |b 105 |e Contributor |
| 700 | 1 | _ | |a Wilmot, George R |b 106 |e Contributor |
| 700 | 1 | _ | |a Schmahmann, Jeremy D |b 107 |e Contributor |
| 700 | 1 | _ | |a Ying, Sarah H |b 108 |e Contributor |
| 700 | 1 | _ | |a Zesiewicz, Theresa A |b 109 |e Contributor |
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