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000258698 1001_ $$aSingh, Manvendra$$b0
000258698 245__ $$aA new human embryonic cell type associated with activity of young transposable elements allows definition of the inner cell mass.
000258698 260__ $$aLawrence, KS$$bPLoS$$c2023
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000258698 520__ $$aThere remains much that we do not understand about the earliest stages of human development. On a gross level, there is evidence for apoptosis, but the nature of the affected cell types is unknown. Perhaps most importantly, the inner cell mass (ICM), from which the foetus is derived and hence of interest in reproductive health and regenerative medicine, has proven hard to define. Here, we provide a multi-method analysis of the early human embryo to resolve these issues. Single-cell analysis (on multiple independent datasets), supported by embryo visualisation, uncovers a common previously uncharacterised class of cells lacking commitment markers that segregates after embryonic gene activation (EGA) and shortly after undergo apoptosis. The discovery of this cell type allows us to clearly define their viable ontogenetic sisters, these being the cells of the ICM. While ICM is characterised by the activity of an Old non-transposing endogenous retrovirus (HERVH) that acts to suppress Young transposable elements, the new cell type, by contrast, expresses transpositionally competent Young elements and DNA-damage response genes. As the Young elements are RetroElements and the cells are excluded from the developmental process, we dub these REject cells. With these and ICM being characterised by differential mobile element activities, the human embryo may be a 'selection arena' in which one group of cells selectively die, while other less damaged cells persist.
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000258698 650_2 $$2MeSH$$aHumans
000258698 650_2 $$2MeSH$$aDNA Transposable Elements: genetics
000258698 650_2 $$2MeSH$$aBlastocyst: metabolism
000258698 650_2 $$2MeSH$$aEmbryo, Mammalian
000258698 650_7 $$2NLM Chemicals$$aDNA Transposable Elements
000258698 7001_ $$aKondrashkina, Aleksandra M$$b1
000258698 7001_ $$aWidmann, Thomas J$$b2
000258698 7001_ $$aCortes, Jose L$$b3
000258698 7001_ $$0P:(DE-2719)2812055$$aBansal, Vikas$$b4$$udzne
000258698 7001_ $$aWang, Jichang$$b5
000258698 7001_ $$aRömer, Christine$$b6
000258698 7001_ $$aGarcia-Canadas, Marta$$b7
000258698 7001_ $$aGarcia-Perez, Jose L$$b8
000258698 7001_ $$00000-0002-1002-1054$$aHurst, Laurence D$$b9
000258698 7001_ $$00000-0002-2053-2384$$aIzsvák, Zsuzsanna$$b10
000258698 773__ $$0PERI:(DE-600)2126773-X$$a10.1371/journal.pbio.3002162$$gVol. 21, no. 6, p. e3002162 -$$n6$$pe3002162$$tPLoS biology$$v21$$x1544-9173$$y2023
000258698 8564_ $$uhttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002162
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