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@ARTICLE{Singh:258698,
      author       = {Singh, Manvendra and Kondrashkina, Aleksandra M and
                      Widmann, Thomas J and Cortes, Jose L and Bansal, Vikas and
                      Wang, Jichang and Römer, Christine and Garcia-Canadas,
                      Marta and Garcia-Perez, Jose L and Hurst, Laurence D and
                      Izsvák, Zsuzsanna},
      title        = {{A} new human embryonic cell type associated with activity
                      of young transposable elements allows definition of the
                      inner cell mass.},
      journal      = {PLoS biology},
      volume       = {21},
      number       = {6},
      issn         = {1544-9173},
      address      = {Lawrence, KS},
      publisher    = {PLoS},
      reportid     = {DZNE-2023-00671},
      pages        = {e3002162},
      year         = {2023},
      abstract     = {There remains much that we do not understand about the
                      earliest stages of human development. On a gross level,
                      there is evidence for apoptosis, but the nature of the
                      affected cell types is unknown. Perhaps most importantly,
                      the inner cell mass (ICM), from which the foetus is derived
                      and hence of interest in reproductive health and
                      regenerative medicine, has proven hard to define. Here, we
                      provide a multi-method analysis of the early human embryo to
                      resolve these issues. Single-cell analysis (on multiple
                      independent datasets), supported by embryo visualisation,
                      uncovers a common previously uncharacterised class of cells
                      lacking commitment markers that segregates after embryonic
                      gene activation (EGA) and shortly after undergo apoptosis.
                      The discovery of this cell type allows us to clearly define
                      their viable ontogenetic sisters, these being the cells of
                      the ICM. While ICM is characterised by the activity of an
                      Old non-transposing endogenous retrovirus (HERVH) that acts
                      to suppress Young transposable elements, the new cell type,
                      by contrast, expresses transpositionally competent Young
                      elements and DNA-damage response genes. As the Young
                      elements are RetroElements and the cells are excluded from
                      the developmental process, we dub these REject cells. With
                      these and ICM being characterised by differential mobile
                      element activities, the human embryo may be a 'selection
                      arena' in which one group of cells selectively die, while
                      other less damaged cells persist.},
      keywords     = {Humans / DNA Transposable Elements: genetics / Blastocyst:
                      metabolism / Embryo, Mammalian / DNA Transposable Elements
                      (NLM Chemicals)},
      cin          = {AG Bansal},
      ddc          = {610},
      cid          = {I:(DE-2719)1210013},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC10281584},
      pubmed       = {pmid:37339119},
      doi          = {10.1371/journal.pbio.3002162},
      url          = {https://pub.dzne.de/record/258698},
}