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001     258764
005     20240403120701.0
024 7 _ |a 10.1016/j.cub.2023.04.065
|2 doi
024 7 _ |a pmid:37220744
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024 7 _ |a 0960-9822
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024 7 _ |a 1879-0445
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037 _ _ |a DZNE-2023-00672
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Ying, Johnson
|b 0
245 _ _ |a Grid cell disruption in a mouse model of early Alzheimer's disease reflects reduced integration of self-motion cues.
260 _ _ |a London
|c 2023
|b Current Biology Ltd.
336 7 _ |a article
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520 _ _ |a Converging evidence from human and rodent studies suggests that disrupted grid cell coding in the medial entorhinal cortex (MEC) underlies path integration behavioral deficits during early Alzheimer's disease (AD). However, grid cell firing relies on both self-motion cues and environmental features, and it remains unclear whether disrupted grid coding can account for specific path integration deficits reported during early AD. Here, we report in the J20 transgenic amyloid beta (Aβ) mouse model of early AD that grid cells were spatially unstable toward the center of the arena, had qualitatively different spatial components that aligned parallel to the borders of the environment, and exhibited impaired integration of distance traveled via reduced theta phase precession. Our results suggest that disrupted early AD grid coding reflects reduced integration of self-motion cues but not environmental information via geometric boundaries, providing evidence that grid cell impairments underlie path integration deficits during early AD.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cues
|2 MeSH
650 _ 2 |a Alzheimer Disease: genetics
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Entorhinal Cortex
|2 MeSH
650 _ 2 |a Action Potentials
|2 MeSH
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a Fourier analysis
|2 Other
650 _ 7 |a amyloid beta
|2 Other
650 _ 7 |a environmental geometry
|2 Other
650 _ 7 |a grid cells
|2 Other
650 _ 7 |a medial entorhinal cortex
|2 Other
650 _ 7 |a path integration
|2 Other
650 _ 7 |a spatial navigation
|2 Other
650 _ 7 |a spatial stability
|2 Other
650 _ 7 |a theta phase precession
|2 Other
650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
700 1 _ |a Reboreda, Antonio
|0 P:(DE-2719)2813728
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700 1 _ |a Yoshida, Motoharu
|0 P:(DE-2719)2811873
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700 1 _ |a Brandon, Mark P
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773 _ _ |a 10.1016/j.cub.2023.04.065
|g Vol. 33, no. 12, p. 2425 - 2437.e5
|0 PERI:(DE-600)2019214-9
|n 12
|p 2425 - 2437.e5
|t Current biology
|v 33
|y 2023
|x 0960-9822
856 4 _ |u https://www.sciencedirect.com/science/article/pii/S096098222300547X
856 4 _ |u https://pub.dzne.de/record/258764/files/DZNE-2023-00672_Restricted.pdf
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