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000258784 041__ $$aEnglish
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000258784 1001_ $$0P:(DE-2719)9001401$$aRakuša, Elena$$b0$$eFirst author$$udzne
000258784 245__ $$aSporadic Use of Antibiotics in Older Adults and the Risk of Dementia: A Nested Case-Control Study Based on German Health Claims Data.
000258784 260__ $$aAmsterdam$$bIOS Press$$c2023
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000258784 520__ $$aAntibiotics for systemic use may increase the risk of neurodegeneration, yet antibiotic therapy may be able to halt or mitigate an episode of neurodegenerative decline.To investigate the association of sporadic use of antibiotics and subsequent dementia risk (including Alzheimer's disease).We used data from the largest public health insurance fund in Germany, the Allgemeine Ortskrankenkasse (AOK). Each of the 35,072 dementia cases aged 60 years and older with a new dementia diagnosis during the observation period from 2006 to 2018 was matched with two control-patients by age, sex, and time since 2006. We ran conditional logistic regression models for dementia risk in terms of odds ratios (OR) as a function of antibiotic use for the entire antibiotic group and for each antibiotic subgroup. We controlled for comorbidities, need for long-term care, hospitalizations, and nursing home placement.Antibiotic use was positively associated with dementia (OR = 1.18, 95% confidence interval (95% CI):1.14-1.22), which became negative after adjustment for comorbidities, at least one diagnosis of bacterial infection or disease, and covariates (OR = 0.93, 95% CI:0.90-0.96). Subgroups of antibiotics were also negatively associated with dementia after controlling for covariates: tetracyclines (OR = 0.94, 95% CI:0.90-0.98), beta-lactam antibacterials, penicillins (OR = 0.93, 95% CI:0.90-0.97), other beta-lactam antibacterials (OR = 0.92, 95% CI:0.88-0.95), macrolides, lincosamides, and streptogramins (OR = 0.88, 95% CI:0.85-0.92), and quinolone antibacterials (OR = 0.96, 95% CI:0.92-0.99).Our results suggest that there was a decreased likelihood of dementia for preceding antibiotic use. The benefits of antibiotics in reducing inflammation and thus the risk of dementia need to be carefully weighed against the increase in antibiotic resistance.
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000258784 650_2 $$2MeSH$$aHumans
000258784 650_2 $$2MeSH$$aMiddle Aged
000258784 650_2 $$2MeSH$$aAged
000258784 650_2 $$2MeSH$$aAnti-Bacterial Agents: adverse effects
000258784 650_2 $$2MeSH$$aCase-Control Studies
000258784 650_2 $$2MeSH$$aComorbidity
000258784 650_2 $$2MeSH$$aDementia: drug therapy
000258784 650_2 $$2MeSH$$aDementia: epidemiology
000258784 650_2 $$2MeSH$$aDementia: diagnosis
000258784 650_2 $$2MeSH$$abeta-Lactams
000258784 650_7 $$2Other$$aAlzheimer’s disease
000258784 650_7 $$2Other$$aAlzheimer’s disease
000258784 650_7 $$2Other$$aantibiotics
000258784 650_7 $$2Other$$aconditional logistic regression
000258784 650_7 $$2Other$$adementia
000258784 650_7 $$2Other$$aepidemiology
000258784 650_7 $$2Other$$anested case-control studies
000258784 650_7 $$2NLM Chemicals$$aAnti-Bacterial Agents
000258784 650_7 $$2NLM Chemicals$$abeta-Lactams
000258784 7001_ $$0P:(DE-2719)2241493$$aFink, Anne$$b1$$udzne
000258784 7001_ $$0P:(DE-2719)2810376$$aTamgüney, Gültekin$$b2$$udzne
000258784 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael$$b3$$udzne
000258784 7001_ $$0P:(DE-2719)2811246$$aDoblhammer, Gabriele$$b4$$eLast author$$udzne
000258784 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-221153$$gVol. 93, no. 4, p. 1329 - 1339$$n4$$p1329 - 1339$$tJournal of Alzheimer's disease$$v93$$x1387-2877$$y2023
000258784 8564_ $$uhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad221153
000258784 8564_ $$uhttps://pub.dzne.de/record/258784/files/DZNE-2023-00678_Restricted.pdf
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