TY  - JOUR
AU  - Rakuša, Elena
AU  - Fink, Anne
AU  - Tamgüney, Gültekin
AU  - Heneka, Michael
AU  - Doblhammer, Gabriele
TI  - Sporadic Use of Antibiotics in Older Adults and the Risk of Dementia: A Nested Case-Control Study Based on German Health Claims Data.
JO  - Journal of Alzheimer's disease
VL  - 93
IS  - 4
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2023-00678
SP  - 1329 - 1339
PY  - 2023
AB  - Antibiotics for systemic use may increase the risk of neurodegeneration, yet antibiotic therapy may be able to halt or mitigate an episode of neurodegenerative decline.To investigate the association of sporadic use of antibiotics and subsequent dementia risk (including Alzheimer's disease).We used data from the largest public health insurance fund in Germany, the Allgemeine Ortskrankenkasse (AOK). Each of the 35,072 dementia cases aged 60 years and older with a new dementia diagnosis during the observation period from 2006 to 2018 was matched with two control-patients by age, sex, and time since 2006. We ran conditional logistic regression models for dementia risk in terms of odds ratios (OR) as a function of antibiotic use for the entire antibiotic group and for each antibiotic subgroup. We controlled for comorbidities, need for long-term care, hospitalizations, and nursing home placement.Antibiotic use was positively associated with dementia (OR = 1.18, 95
KW  - Humans
KW  - Middle Aged
KW  - Aged
KW  - Anti-Bacterial Agents: adverse effects
KW  - Case-Control Studies
KW  - Comorbidity
KW  - Dementia: drug therapy
KW  - Dementia: epidemiology
KW  - Dementia: diagnosis
KW  - beta-Lactams
KW  - Alzheimer’s disease (Other)
KW  - Alzheimer’s disease (Other)
KW  - antibiotics (Other)
KW  - conditional logistic regression (Other)
KW  - dementia (Other)
KW  - epidemiology (Other)
KW  - nested case-control studies (Other)
KW  - Anti-Bacterial Agents (NLM Chemicals)
KW  - beta-Lactams (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:37182873
DO  - DOI:10.3233/JAD-221153
UR  - https://pub.dzne.de/record/258784
ER  -