TY  - JOUR
AU  - Breit, Sorin
AU  - Milosevic, Luka
AU  - Naros, Georgios
AU  - Cebi, Idil
AU  - Weiss, Daniel
AU  - Gharabaghi, Alireza
TI  - Structural-Functional Correlates of Response to Pedunculopontine Stimulation in a Randomized Clinical Trial for Axial Symptoms of Parkinson's Disease.
JO  - Journal of Parkinson's Disease
VL  - 13
IS  - 4
SN  - 1877-7171
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2023-00680
SP  - 563 - 573
PY  - 2023
AB  - Axial symptoms of Parkinson's disease (PD) can be debilitating and are often refractory to conventional therapies such as dopamine replacement therapy and deep brain stimulation (DBS) of the subthalamic nuclei (STN).Evaluate the efficacy of bilateral DBS of the pedunculopontine nucleus area (PPNa) and investigate structural and physiological correlates of clinical response.A randomized, double-blind, cross-over clinical trial was employed to evaluate the efficacy of bilateral PPNa-DBS on axial symptoms. Lead positions and neuronal activity were evaluated with respect to clinical response. Connectomic cortical activation profiles were generated based on the volumes of tissue activated.PPNa-DBS modestly improved (p = 0.057) axial symptoms in the medication-off condition, with greatest positive effects on gait symptoms (p = 0.027). Electrode placements towards the anterior commissure (ρ= 0.912; p = 0.011) or foramen caecum (ρ= 0.853; p = 0.031), near the 50
KW  - Humans
KW  - Parkinson Disease: therapy
KW  - Parkinson Disease: drug therapy
KW  - Deep Brain Stimulation: methods
KW  - Subthalamic Nucleus
KW  - Pedunculopontine Tegmental Nucleus
KW  - Gait
KW  - Parkinson’s disease (Other)
KW  - Deep brain stimulation (Other)
KW  - Parkinson’s disease (Other)
KW  - pedunculopontine nucleus (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC10357146
C6  - pmid:37092235
DO  - DOI:10.3233/JPD-225031
UR  - https://pub.dzne.de/record/258786
ER  -