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@ARTICLE{Hipke:258928,
      author       = {Hipke, Katrin and Pitter, Bettina and Hruscha, Alexander
                      and van Bebber, Frauke and Modic, Miha and Bansal, Vikas and
                      Lewandowski, Sebastian A and Orozco, Denise and Edbauer,
                      Dieter and Bonn, Stefan and Haass, Christian and Pohl,
                      Ulrich and Montanez, Eloi and Schmid, Bettina},
      title        = {{L}oss of {TDP}-43 causes ectopic endothelial sprouting and
                      migration defects through increased fibronectin, vcam 1 and
                      integrin α4/β1.},
      journal      = {Frontiers in cell and developmental biology},
      volume       = {11},
      issn         = {2296-634X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DZNE-2023-00700},
      pages        = {1169962},
      year         = {2023},
      abstract     = {Aggregation of the Tar DNA-binding protein of 43 kDa
                      (TDP-43) is a pathological hallmark of amyotrophic lateral
                      sclerosis and frontotemporal dementia and likely contributes
                      to disease by loss of nuclear function. Analysis of TDP-43
                      function in knockout zebrafish identified an endothelial
                      directional migration and hypersprouting phenotype during
                      development prior lethality. In human umbilical vein cells
                      (HUVEC) the loss of TDP-43 leads to hyperbranching. We
                      identified elevated expression of FIBRONECTIN 1 (FN1), the
                      VASCULAR CELL ADHESION MOLECULE 1 (VCAM1), as well as their
                      receptor INTEGRIN α4β1 (ITGA4B1) in HUVEC cells.
                      Importantly, reducing the levels of ITGA4, FN1, and VCAM1
                      homologues in the TDP-43 loss-of-function zebrafish rescues
                      the angiogenic defects indicating the conservation of human
                      and zebrafish TDP-43 function during angiogenesis. Our study
                      identifies a novel pathway regulated by TDP-43 important for
                      angiogenesis during development.},
      keywords     = {ALS (Other) / TDP-43 (Other) / angiogenesis (Other) /
                      neurodegeneration (Other) / zebrafish (Other)},
      cin          = {AG Schmid / AG Bansal / AG Edbauer / AG Haass},
      ddc          = {570},
      cid          = {I:(DE-2719)1140002 / I:(DE-2719)1210013 /
                      I:(DE-2719)1110004 / I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352) / 354 - Disease
                      Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-352 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37384248},
      pmc          = {pmc:PMC10299809},
      doi          = {10.3389/fcell.2023.1169962},
      url          = {https://pub.dzne.de/record/258928},
}