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| Home > Publications Database > Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. > print |
| Home > Publications Database > Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. > print |
| 001 | 258928 | ||
| 005 | 20240612120605.0 | ||
| 024 | 7 | _ | |a 10.3389/fcell.2023.1169962 |2 doi |
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| 037 | _ | _ | |a DZNE-2023-00700 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Hipke, Katrin |0 P:(DE-HGF)0 |b 0 |e First author |
| 245 | _ | _ | |a Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. |
| 260 | _ | _ | |a Lausanne |c 2023 |b Frontiers Media |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knockout zebrafish identified an endothelial directional migration and hypersprouting phenotype during development prior lethality. In human umbilical vein cells (HUVEC) the loss of TDP-43 leads to hyperbranching. We identified elevated expression of FIBRONECTIN 1 (FN1), the VASCULAR CELL ADHESION MOLECULE 1 (VCAM1), as well as their receptor INTEGRIN α4β1 (ITGA4B1) in HUVEC cells. Importantly, reducing the levels of ITGA4, FN1, and VCAM1 homologues in the TDP-43 loss-of-function zebrafish rescues the angiogenic defects indicating the conservation of human and zebrafish TDP-43 function during angiogenesis. Our study identifies a novel pathway regulated by TDP-43 important for angiogenesis during development. |
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| 650 | _ | 7 | |a ALS |2 Other |
| 650 | _ | 7 | |a TDP-43 |2 Other |
| 650 | _ | 7 | |a angiogenesis |2 Other |
| 650 | _ | 7 | |a neurodegeneration |2 Other |
| 650 | _ | 7 | |a zebrafish |2 Other |
| 700 | 1 | _ | |a Pitter, Bettina |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Hruscha, Alexander |0 P:(DE-2719)2009882 |b 2 |
| 700 | 1 | _ | |a van Bebber, Frauke |0 P:(DE-2719)9000319 |b 3 |
| 700 | 1 | _ | |a Modic, Miha |b 4 |
| 700 | 1 | _ | |a Bansal, Vikas |0 P:(DE-2719)2812055 |b 5 |
| 700 | 1 | _ | |a Lewandowski, Sebastian A |b 6 |
| 700 | 1 | _ | |a Orozco, Denise |0 P:(DE-2719)9000242 |b 7 |
| 700 | 1 | _ | |a Edbauer, Dieter |0 P:(DE-2719)2231621 |b 8 |
| 700 | 1 | _ | |a Bonn, Stefan |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Haass, Christian |0 P:(DE-2719)2202037 |b 10 |
| 700 | 1 | _ | |a Pohl, Ulrich |b 11 |
| 700 | 1 | _ | |a Montanez, Eloi |b 12 |
| 700 | 1 | _ | |a Schmid, Bettina |0 P:(DE-2719)2241638 |b 13 |e Last author |
| 773 | _ | _ | |a 10.3389/fcell.2023.1169962 |g Vol. 11, p. 1169962 |0 PERI:(DE-600)2737824-X |p 1169962 |t Frontiers in cell and developmental biology |v 11 |y 2023 |x 2296-634X |
| 856 | 4 | _ | |u https://www.frontiersin.org/articles/10.3389/fcell.2023.1169962/full |
| 856 | 4 | _ | |u https://pub.dzne.de/record/258928/files/DZNE-2023-00700.pdf |y OpenAccess |
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