%0 Journal Article
%A Brauchle, Felix
%A Rapp, Daniel
%A Senel, Makbule
%A Huss, André
%A Dreyhaupt, Jens
%A Klose, Veronika
%A Süße, Marie
%A Stürner, Klarissa Hanja
%A Leypoldt, Frank
%A Tumani, Hayrettin
%A Lewerenz, Jan
%T Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases - a retrospective cross-sectional study.
%J Frontiers in neurology
%V 14
%@ 1664-2295
%C Lausanne
%I Frontiers Research Foundation
%M DZNE-2023-00706
%P 1193015
%D 2023
%X The polyspecific intrathecal immune response (PSIIR), aka MRZ reaction (M = measles, R = rubella, Z = zoster, optionally Herpes simplex virus, HSV) is defined as intrathecal immunoglobulin synthesis (IIS) for two or more unrelated viruses. Although an established cerebrospinal fluid (CSF) biomarker for multiple sclerosis (MS), a chronic autoimmune-inflammatory neurological disease (CAIND) of the central nervous system (CNS) usually starting in young adulthood, the full spectrum of CAINDs with a positive PSIIR remains ill defined.In this retrospective, cross-sectional study, patients with CSF-positive oligoclonal bands (OCB) and - to enrich for non-MS diagnoses - aged ≥50 years were enrolled.Of 415 with PSIIR testing results (MRZ, HSV optional), 76 were PSIIR-positive. Of these, 25 (33
%K MRZ reaction (Other)
%K autoimmue disease (Other)
%K multiple sclerosis (Other)
%K neuroinflammation (Other)
%K polyspecific intrathecal immune response (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37396770
%2 pmc:PMC10311206
%R 10.3389/fneur.2023.1193015
%U https://pub.dzne.de/record/258940