TY  - JOUR
AU  - Brauchle, Felix
AU  - Rapp, Daniel
AU  - Senel, Makbule
AU  - Huss, André
AU  - Dreyhaupt, Jens
AU  - Klose, Veronika
AU  - Süße, Marie
AU  - Stürner, Klarissa Hanja
AU  - Leypoldt, Frank
AU  - Tumani, Hayrettin
AU  - Lewerenz, Jan
TI  - Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases - a retrospective cross-sectional study.
JO  - Frontiers in neurology
VL  - 14
SN  - 1664-2295
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2023-00706
SP  - 1193015
PY  - 2023
AB  - The polyspecific intrathecal immune response (PSIIR), aka MRZ reaction (M = measles, R = rubella, Z = zoster, optionally Herpes simplex virus, HSV) is defined as intrathecal immunoglobulin synthesis (IIS) for two or more unrelated viruses. Although an established cerebrospinal fluid (CSF) biomarker for multiple sclerosis (MS), a chronic autoimmune-inflammatory neurological disease (CAIND) of the central nervous system (CNS) usually starting in young adulthood, the full spectrum of CAINDs with a positive PSIIR remains ill defined.In this retrospective, cross-sectional study, patients with CSF-positive oligoclonal bands (OCB) and - to enrich for non-MS diagnoses - aged ≥50 years were enrolled.Of 415 with PSIIR testing results (MRZ, HSV optional), 76 were PSIIR-positive. Of these, 25 (33
KW  - MRZ reaction (Other)
KW  - autoimmue disease (Other)
KW  - multiple sclerosis (Other)
KW  - neuroinflammation (Other)
KW  - polyspecific intrathecal immune response (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37396770
C2  - pmc:PMC10311206
DO  - DOI:10.3389/fneur.2023.1193015
UR  - https://pub.dzne.de/record/258940
ER  -