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@ARTICLE{Murthy:259686,
      author       = {Murthy, Megha and Rizzu, Patrizia and Heutink, Peter and
                      Mill, Jonathan and Lashley, Tammaryn and Bettencourt,
                      Conceição},
      title        = {{E}pigenetic {A}ge {A}cceleration in {F}rontotemporal
                      {L}obar {D}egeneration: {A} {C}omprehensive {A}nalysis in
                      the {B}lood and {B}rain.},
      journal      = {Cells},
      volume       = {12},
      number       = {14},
      issn         = {2073-4409},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2023-00758},
      pages        = {1922},
      year         = {2023},
      abstract     = {Frontotemporal lobar degeneration (FTLD) includes a
                      heterogeneous group of disorders pathologically
                      characterized by the degeneration of the frontal and
                      temporal lobes. In addition to major genetic contributors of
                      FTLD such as mutations in MAPT, GRN, and C9orf72, recent
                      work has identified several epigenetic modifications
                      including significant differential DNA methylation in DLX1,
                      and OTUD4 loci. As aging remains one of the major risk
                      factors for FTLD, we investigated the presence of
                      accelerated epigenetic aging in FTLD compared to controls.
                      We calculated epigenetic age in both peripheral blood and
                      brain tissues of multiple FTLD subtypes using several DNA
                      methylation clocks, i.e., DNAmClockMulti, DNAmClockHannum,
                      DNAmClockCortical, GrimAge, and PhenoAge, and determined age
                      acceleration and its association with different cellular
                      proportions and clinical traits. Significant epigenetic age
                      acceleration was observed in the peripheral blood of both
                      frontotemporal dementia (FTD) and progressive supranuclear
                      palsy (PSP) patients compared to controls with
                      DNAmClockHannum, even after accounting for confounding
                      factors. A similar trend was observed with both
                      DNAmClockMulti and DNAmClockCortical in post-mortem frontal
                      cortex tissue of PSP patients and in FTLD cases harboring
                      GRN mutations. Our findings support that increased
                      epigenetic age acceleration in the peripheral blood could be
                      an indicator for PSP and to a smaller extent, FTD.},
      keywords     = {Humans / Frontotemporal Dementia / Frontotemporal Lobar
                      Degeneration: genetics / Brain / Supranuclear Palsy,
                      Progressive: genetics / Mutation: genetics /
                      Ubiquitin-Specific Proteases / DNA methylation aging (Other)
                      / epigenetic clock (Other) / frontotemporal dementia (Other)
                      / frontotemporal lobar degeneration (Other) / progressive
                      supranuclear palsy (Other) / OTUD4 protein, human (NLM
                      Chemicals) / Ubiquitin-Specific Proteases (NLM Chemicals)},
      cin          = {AG Rizzu / AG Heutink},
      ddc          = {570},
      cid          = {I:(DE-2719)1210009 / I:(DE-2719)1210002},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37508584},
      pmc          = {pmc:PMC10378390},
      doi          = {10.3390/cells12141922},
      url          = {https://pub.dzne.de/record/259686},
}